Evidence map›Paper›PMID 32102886›Full record

ArticleJournal of virology2020

Long Noncoding RNA NRAV Promotes Respiratory Syncytial Virus Replication by Targeting the MicroRNA miR-509-3p/Rab5c Axis To Regulate Vesicle Transportation.

Jian Li, Miao Li, Xiuli Wang, Mengfei Sun, Cuiqing Ma, Wenzhang Liang, Xue Gao, Lin Wei

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jian Li *Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Miao Li *Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Xiuli Wang *Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Mengfei SunDepartment of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Cuiqing MaDepartment of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Wenzhang LiangDepartment of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Xue GaoDepartment of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China.
Lin WeiDepartment of Immunology, Hebei Medical University, Shijiazhuang, Hebei, China weilin@hebmu.edu.cn.
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is an enveloped RNA virus which is responsible for approximately 80% of lower respiratory tract infections in children. Current lines of evidence have supported the functional involvement of long noncoding RNA (lncRNA) in many viral infectious diseases. However, the overall biological effect and clinical role of lncRNAs in RSV infection remain unclear. In this study, lncRNAs related to respiratory virus infection were obtained from the lncRNA database, and we collected 144 clinical sputum specimens to identify lncRNAs related to RSV infection. Quantitative PCR (qPCR) detection indicated that the expression of lncRNA negative regulator of antiviral response (NRAV) in RSV-positive patients was significantly lower than that in uninfected patients, but lncRNA psoriasis-associated non-protein coding RNA induced by stress (PRINS), nuclear paraspeckle assembly transcript 1 (NEAT1), and Nettoie Salmonella pas Theiler's (NeST) showed no difference

Indexed as

A549 CellsAdolescentCell Line, TumorChildChild, PreschoolDown-RegulationFemaleGene ExpressionGene Knockdown TechniquesHumansIn Situ Hybridization, FluorescenceMaleMicroRNAsrab5 GTP-Binding ProteinsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsMicroRNAsMIRN509 microRNA, humanNEAT1 long non-coding RNA, humanRAB5C protein, humanrab5 GTP-Binding ProteinsRNA, Long Noncodinglong noncoding RNAmiR-509-3pNRAVRab5crespiratory epithelial cellsrespiratory syncytial virus

Identifiers

PMID32102886
PMCPMC7199404
OpenAlexW3008450997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.