Evidence map›Paper›PMID 32102878›Full record

ArticleJournal of virology2020

The High Content of Fructose in Human Semen Competitively Inhibits Broad and Potent Antivirals That Target High-Mannose Glycans.

Jacklyn Johnson, Manuel G Flores, John Rosa, Changze Han, Alicia M Salvi, Kris A DeMali, Jennifer R Jagnow, Amy Sparks, Hillel Haim

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jacklyn JohnsonDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Manuel G FloresDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
John RosaDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Changze HanDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Alicia M SalviDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Kris A DeMaliDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Jennifer R JagnowIn Vitro Fertilization and Reproductive Testing Laboratory, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Amy SparksIn Vitro Fertilization and Reproductive Testing Laboratory, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Hillel HaimDepartment of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA Hillel-haim@uiowa.edu.
University of Iowa · USUniversity of Iowa Hospitals and Clinics · US

Funding

Training in Molecular Virology, Viral Pathogenesis and Viral VectorsT32AI007533 · NIAID · UNIVERSITY OF IOWA · PI Stanley Perlman · 1998 to 2026
$2.5M
NIAID NIH HHS T32 AI007533
6 · The paper itself

Abstract

Semen is the primary transmission vehicle for various pathogenic viruses. Initial steps of transmission, including cell attachment and entry, likely occur in the presence of semen. However, the unstable nature of human seminal plasma and its toxic effects on cells in culture limit the ability to study

Indexed as

AdultAnti-Infective AgentsAntiviral AgentsCell Line, Tumorenv Gene Products, Human Immunodeficiency VirusFructoseGene Products, envGenes, envHEK293 CellsHIV-1HIV InfectionsHumansMaleMannosePolysaccharidesSemenAnti-Infective AgentsAntiviral Agentsenv Gene Products, Human Immunodeficiency VirusFructoseGene Products, envMannosePolysaccharidesantibodieshigh-mannose glycansHIV-1human semenlectinsmicrobicidesseminal plasma simulantsexual transmission

Identifiers

PMID32102878
PMCPMC7163146
OpenAlexW3007425615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.