Evidence map›Paper›PMID 32102852›Full record

ArticleJournal of clinical microbiology2020

Validation of an Epstein-Barr Virus Antibody Risk Stratification Signature for Nasopharyngeal Carcinoma by Use of Multiplex Serology.

Julia Simon, Zhiwei Liu, Nicole Brenner, Kelly J Yu, Wan-Lun Hsu, Cheng-Ping Wang, Yin-Chu Chien, Anna E Coghill, Chien-Jen Chen, Julia Butt and 4 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06129201 (Development of a Machine Learning Model for Nasopharyngeal Carcinoma Screening Based on Tongue Imaging), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06129201 unknown statusnot on this mapstarted 2023, after this paper: background citation

Development of a Machine Learning Model for Nasopharyngeal Carcinoma Screening Based on Tongue Imaging: a Prospective Multicenter Cross-sectional Study

TypeobservationalSponsorFifth Affiliated Hospital, Sun Yat-Sen UniversityRan2023 to 2025Enrolled5,000ConditionsNasopharyngeal CarcinomaArmsTongue image
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. The Epstein-Barr Virus Nuclear Antigen 1 Variant Associated with Nasopharyngeal Carcinoma Defines the Sequence Criteria for Serologic Risk Prediction.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  8. Article
  9. Article
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  11. Could MMP3 and MMP9 Serve as Biomarkers in EBV-Related Oropharyngeal Cancer.International journal of molecular sciences · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  16. Article
  17. Identification of anti-Epstein-Barr virus (EBV) antibody signature in EBV-associated gastric carcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 4 countries.

Julia Simon *Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany J.simon@dkfz.de zhiwei.liu@nih.gov.
Zhiwei Liu *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA J.simon@dkfz.de zhiwei.liu@nih.gov.ORCID 0000-0002-0136-651X
Nicole BrennerInfections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kelly J YuDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Wan-Lun HsuGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Cheng-Ping WangDepartment of Otolaryngology, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Yin-Chu ChienGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Anna E CoghillDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Chien-Jen ChenGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Julia ButtInfections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carla ProiettiAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
Denise L DoolanAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
Allan Hildesheim *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Tim Waterboer *Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Research Center · DENational Cancer Institute · USAustralian Institute of Tropical Health and Medicine · AUNational Taiwan University · TWMoffitt Cancer Center · USNational Health Research Institutes · TWNational Taiwan University Hospital · TW

Funding

Viral and Host Factors Associated with NPCZIACP010211 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ENGELS, ERIC A · 2010 to 2025
$6.1M
6 · The paper itself

Abstract

Serological testing for nasopharyngeal carcinoma (NPC) has recently been reinvigorated by the implementation of novel Epstein-Barr virus (EBV)-specific IgA and IgG antibodies from a proteome array. Although proteome arrays are well suited for comprehensive antigen selection, they are not applicable for large-scale studies. We adapted a 13-marker EBV antigen signature for NPC risk identified by proteome arrays to multiplex serology to establish an assay for large-scale studies. Taiwanese NPC cases (

Indexed as

CarcinomaEpstein-Barr Virus InfectionsNasopharyngeal NeoplasmsAntibodies, ViralAntigens, ViralHerpesvirus 4, HumanHumansImmunoglobulin ANasopharyngeal CarcinomaRisk AssessmentAntibodies, ViralAntigens, ViralImmunoglobulin AEpstein-Barr virusmultiplex serologynasopharyngeal carcinomarisk stratification signaturevalidation

Identifiers

PMID32102852
PMCPMC7180240
OpenAlexW3007338108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.