ArticleJournal of epidemiology and community health2020
Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort.
Article in Journal of epidemiology and community health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal effects of subjective aging on health and longevity: An updated meta-analysis.Psychology and aging · 2023Pooled it
- Systemic Inflammation and Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease and Chronic Kidney Disease.JACC. Advances · 2026Article
- Dose-Response Association Between Handgrip Strength and All-Cause Mortality Across Different Levels of Systemic Inflammation.Journal of cachexia, sarcopenia and muscle · 2026Article
- Comparison of all-cause mortality risk factors in a population-based cohort study.Scientific reports · 2026Article
- Article
- Non-linear correlation between the ratio of high-density lipoprotein cholesterol to C-reactive protein and all-cause mortality in adults: an extensive study based on nationwide data.Population health metrics · 2025Article
- Prolonged Hospital Stay in Hypertensive Patients: Retrospective Analysis of Risk Factors and Interactions.Nursing reports (Pavia, Italy) · 2025Article
- The combined effect of CRP and blood pressure on the risk of mortality in patients with type 2 diabetes.Scientific reports · 2025Article
- The role of C-reactive protein in predicting all-cause mortality among Chinese arthritis patients: implications for public health education and promotion.Frontiers in public health · 2025Article
- Tooth loss and mortality risk: the mediating role of hs-CRP in a Chinese cohort.Frontiers in oral health · 2025Article
- Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet.Scientific reports · 2024Article
- Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study.GeroScience · 2024Article
- Phenotypic age mediates effects of Life's Essential 8 on reduced mortality risk in US adults.Precision clinical medicine · 2024Article
- Association Between the Red Blood Cell Distribution Width and 30-Day Mortality in Intensive Care Patients Undergoing Cardiac Surgery: A Retrospective Observational Study Based on the Medical Information Mart for Intensive Care-IV Database.Annals of laboratory medicine · 2024Observational
- Association of C-reactive protein with all-cause and cause-specific mortality in people with gout.European journal of medical research · 2024Article
- High-sensitivity C-reactive protein is a predictor of all-cause mortality in a rural Japanese population.Journal of clinical laboratory analysis · 2024Article
- Blood inflammatory markers and mortality in the US population: A Health and Retirement Survey (HRS) analysis.PloS one · 2023Article
- Article
- Dairy product consumption reduces cardiovascular mortality: results after 8 year follow-up of ELSA-Brasil.European journal of nutrition · 2022Article
- Association of Serum 25(OH)D, Cadmium, CRP With All-Cause, Cause-Specific Mortality: A Prospective Cohort Study.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-sensitivity C reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of hsCRP with the risk of all-cause mortality in a multiethnic Brazilian population.
methodsBaseline data (2008-2010) of a cohort of 14 238 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. hsCRP was assayed with immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after a mean follow-up of 8.0±1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease.
resultsThe risk of death increased steadily by quartiles of hsCRP, from 1.45 (95% CI 1.05 to 2.01) in quartile 2 to 1.95 (95% CI 1.42 to 2.69) in quartile 4, compared with quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the HR was unaffected by the exclusion of participants who had self-reported medical history of diabetes, cancer and chronic obstructive pulmonary disease.
conclusionsOur study shows that hsCRP level is associated with mortality in a highly admixed population, independent of a large set of lifestyle and clinical variables.
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