Trial reportBMJ (Clinical research ed.)2020
Cost effectiveness of an intervention to increase uptake of hepatitis C virus testing and treatment (HepCATT): cluster randomised controlled trial in primary care.
Trial report in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Behavioral interventions to improve population health outreach for hepatitis C screening: randomized clinical trial.BMJ (Clinical research ed.) · 2021Trial
- Application of machine-learning algorithms to identify the key determinants of risk for HIV, hepatitis C and hepatitis B in primary care settings.BMC infectious diseases · 2026Article
- Strategy for Hepatitis B and C Virus Testing Campaigns Through Web Services and Digital Advertising in Japan: Nationwide Cross-Sectional Study With Correspondence Analysis.Journal of medical Internet research · 2026Article
- The Camden and Islington Viral Hepatitis Identification Tool (CIVHIT): Use of a Clinical Database Case-Finding Tool for Hepatitis B, Hepatitis C and HIV in Primary Care.Journal of viral hepatitis · 2025Article
- Pilot postal birth cohort hepatitis C virus screening in UK primary care: HepCAPP study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Results from a retrospective case finding and re-engagement exercise for people previously diagnosed with hepatitis C virus to increase uptake of directly acting antiviral treatment.BMC public health · 2024Article
- Development of educational package and participatory consumer groups to improve food handling practices in food establishments in Sri Lanka.SAGE open medicine · 2024Article
- Integrating Management of Hepatitis C Infection into Primary Care: the Key to Hepatitis C Elimination Efforts.Journal of general internal medicine · 2022Review
- Developing a primary care-initiated hepatitis C treatment pathway in Scotland: a qualitative study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Article
- Finding Cases of Hepatitis C for Treatment Using Automated Screening in the Emergency Department is Effective, but What Is the Cost?Canadian journal of gastroenterology & hepatology · 2022Article
- Eliminating hepatitis C: time to embrace primary care's critical role?The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
- Provider-related barriers and enablers to the provision of hepatitis C treatment by general practitioners in Scotland: A behaviour change analysis.Journal of viral hepatitis · 2021Article
- Increasing uptake of hepatitis C virus infection case-finding, testing, and treatment in primary care: evaluation of the HepCATT (Hepatitis C Assessment Through to Treatment) trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the effectiveness and cost effectiveness of a complex intervention in primary care that aims to increase uptake of hepatitis C virus (HCV) case finding and treatment.
designPragmatic, two armed, practice level, cluster randomised controlled trial and economic evaluation. SETTING AND
participants45 general practices in South West England (22 randomised to intervention and 23 to control arm). Outcome data were collected from all intervention practices and 21/23 control practices. Total number of flagged patients was 24 473 (about 5% of practice list).
interventionElectronic algorithm and flag on practice systems identifying patients with HCV risk markers (such as history of opioid dependence or HCV tests with no evidence of referral to hepatology), staff educational training in HCV, and practice posters/leaflets to increase patients' awareness. Flagged patients were invited by letter for an HCV test (with one follow-up) and had on-screen pop-ups to encourage opportunistic testing. The intervention lasted one year, with practices recruited April to December 2016.
main outcome measuresPrimary outcome: uptake of HCV testing. SECONDARY OUTCOMES: number of positive HCV tests and yield (proportion HCV positive); HCV treatment assessment at hepatology; cost effectiveness.
resultsBaseline HCV testing of flagged patients (six months before study start) was 608/13 097 (4.6%) in intervention practices and 380/11 376 (3.3%) in control practices. During the study 2071 (16%) of flagged patients in the intervention practices and 1163 (10%) in control practices were tested for HCV: overall intervention effect as an adjusted rate ratio of 1.59 (95% confidence interval 1.21 to 2.08; P<0.001). HCV antibodies were detected in 129 patients from intervention practices and 51 patients from control practices (adjusted rate ratio 2.24, 1.47 to 3.42) with weak evidence of an increase in yield (6.2%
conclusionHepCATT had a modest impact but is a low cost intervention that merits optimisation and implementation as part of an NHS strategy to increase HCV testing and treatment.
trial registrationISRCTN61788850.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.