Observational studyBMC anesthesiology2020
Monitoring of anesthetic depth and EEG band power using phase lag entropy during propofol anesthesia.
Observational study in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03299621 (Anesthetic Depth Using PLE), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anesthetic Depth Using PLE (Phase Lag Entropy)
Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Predicting depth of anaesthesia from single-channel EEG using a deep TCN-BiLSTM-attention model with EWMA.Scientific reports · 2026Article
- Depth of anesthesia monitoring: Current evidence, clinical impact, and future directions.The Journal of international medical research · 2026Review
- Comparative analysis of processed EEG indices and entropy-based metrics for assessing anesthetic depth: a scoping review - PRISMA-ScR.BMC biomedical engineering · 2026Article
- Mechanism of cognitive impairment after laparoscopic surgery and nursing application progress based on EEG monitoring.Frontiers in neurology · 2025Review
- Effect of remimazolamJournal of biomedical research · 2023Article
- Low-intensity transcranial ultrasound stimulation modulates neural activities in mice under propofol anaesthesia.BMC neuroscience · 2023Article
- The influence of stimulating electrode conditions on electrically evoked potentials and resistance in suprachoroidal transretinal stimulation.Japanese journal of ophthalmology · 2023Article
- Alpha-power in electroencephalography as good outcome predictor for out-of-hospital cardiac arrest survivors.Scientific reports · 2022Observational
- How general anesthetics work: from the perspective of reorganized connections within the brain.Korean journal of anesthesiology · 2022Review
- Article
- Brain Activity Characteristics of Patients With Disorders of Consciousness in the EEG Resting State Paradigm: A Review.Frontiers in systems neuroscience · 2022Review
- Phase Lag Entropy as a Surrogate Measurement of Hypnotic Depth during Sevoflurane Anesthesia.Medicina (Kaunas, Lithuania) · 2021Article
- Monitoring of Anesthesia by Bispectral Analysis of EEG Signals.Computational and mathematical methods in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhase lag entropy (PLE) is a novel anesthetic depth indicator that uses four-channel electroencephalography (EEG) to measure the temporal pattern diversity in the phase relationship of frequency signals in the brain. The purpose of the study was to evaluate the anesthetic depth monitoring using PLE and to evaluate the correlation between PLE and bispectral index (BIS) values during propofol anesthesia.
methodsIn thirty-five adult patients undergoing elective surgery, anesthesia was induced with propofol using target-controlled infusion (the Schneider model). We recorded the PLE value, raw EEG, BIS value, and hemodynamic data when the target effect-site concentration (Ce) of propofol reached 2, 3, 4, 5, and 6 μg/ml before intubation and 6, 5, 4, 3, 2 μg/ml after intubation and injection of muscle relaxant. We analyzed whether PLE and raw EEG data from the PLE monitor reflected the anesthetic depth as the Ce of propofol changed, and whether PLE values were comparable to BIS values.
resultsPLE values were inversely correlated to changes in propofol Ce (propofol Ce from 0 to 6.0 μg/ml, r
conclusionsThe PLE value is a useful anesthetic depth indicator, similar to the BIS value, during propofol anesthesia. Spectral analysis of EEG acquired from the PLE monitor demonstrated the typical patterns seen in propofol anesthesia.
trial registrationThis clinical trial was retrospectively registered at ClinicalTrials.gov at October 2017 (NCT03299621).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.