Evidence map›Paper›PMID 32102663›Full record

ArticleBMC nephrology2020

Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia.

Adela Arapović, Katarina Vukojević, Natalija Filipović, Merica Glavina Durdov, Danica Ljubanović-Galešić, Mirna Saraga-Babić, Sandra Prgomet, Ana Simičić Majce, Anja Belavić, Dijana Borić Škaro and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Adela ArapovićDepartment of Pediatrics, University Hospital Centre Split, 21000, Split, Croatia.
Katarina VukojevićDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia. kvukojev@gmail.com.ORCID 0000-0003-2182-2890
Natalija FilipovićDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Merica Glavina DurdovDepartment of Pathology, University Hospital Centre Split, 21000, Split, Croatia.
Danica Ljubanović-GalešićDepartment of Pathology, Clinical Hospital Dubrava, 10000, Zagreb, Croatia.
Mirna Saraga-BabićDepartment of Anatomy, Histology and Embryology, University of Split School of Medicine, Šoltanska 2, 21000, Split, Croatia.
Sandra PrgometDepartment of Pediatrics, University Hospital Centre Split, 21000, Split, Croatia.
Ana Simičić MajceDepartment of Pediatrics, University Hospital Centre Split, 21000, Split, Croatia.
Anja BelavićDivision for School Medicine, Mental Health and Addiction Prevention, Croatian Institue of Public Health, 10000, Zagreb, Croatia.
Dijana Borić ŠkaroDepartment of Nephrology, University Hospital Centre Split, 21000, Split, Croatia.
Dragan LjutićUniversity of Split School of Medicine, 21000, Split, Croatia.
Marijan SaragaDepartment of Pediatrics, University Hospital Centre Split, 21000, Split, Croatia.
University of Split · HRUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInformation about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia.

methodsOut of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Kidney allograft biopsy, and re-biopsy were excluded. The biopsy sections were examined under light microscopy, immunofluorescence and electron microscopy. The data was reviewed to determine the pathohistological spectrum and clinicopathologic correlations. We retrospectively analyzed kidney biopsy data from 2008 to 2017 and compared them to that between 1995 and 2005.

resultsThe mean age of patients was 9.84 ± 5.4 years. Male:female ratio was 1.2:1. The main indications for biopsy were pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%). The most common pathohistological findings were IgA nephropathy (IgAN, 24.1%), minimal change disease (MCD, 16.7%), Henoch-Schönlein purpura glomerulonephritis (HSPN, 14.8%), Alport syndrome and focal segmental glomerulosclerosis (AS and FSGS, 11.1% each), tubulointerstitial nephritis and membranous glomerulopathy (TIN and MGN, 3.7% each), while other cases were diagnosed rarely.

conclusionsChanges in epidemiology of renal diseases in children between the analyzed periods showed an increasing trend of IgAN, MCD, HSPN, AS and FSGS, while mesangioproliferative glomerulonephritis (MesPGN) and endoproliferative glomerulonephritis (EDGN) showed a decreasing trend that can be explained with the new pathohistological classification.

Indexed as

AdolescentBiopsyChildChild, PreschoolCroatiaFemaleGlomerular Filtration RateGlomerulonephritis, IGAHumansKidneyKidney DiseasesMaleMicroscopy, ElectronNephritisNephrotic SyndromeRetrospective StudiesEpidemiologyNephrotic syndromeRegistriesRenal biopsy

Identifiers

PMID32102663
PMCPMC7045640
OpenAlexW3012403758

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.