Evidence map›Paper›PMID 32102661›Full record

ArticleMolecular brain2020

A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.

Lyndsey M Konen, Amanda L Wright, Gordon A Royle, Gary P Morris, Benjamin K Lau, Patrick W Seow, Raphael Zinn, Luke T Milham, Christopher W Vaughan, Bryce Vissel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. In vitro human ion channel assays predictive of drug-induced seizure.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  7. Review
  8. Review
  9. Imbalance inInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Mitochondrial calcium cycling in neuronal function and neurodegeneration.Frontiers in cell and developmental biology · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Lyndsey M KonenCentre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
Amanda L WrightDepartment of Biomedical Sciences, Faculty of Medicine & Health Sciences, Macquarie University, Sydney, New South Wales, 2109, Australia.
Gordon A RoyleMiddlemore Hospital, Counties Manukau DHB, Otahuhu, Auckland, 1062, New Zealand.
Gary P MorrisCentre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
Benjamin K LauKolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, 2065, Australia.
Patrick W SeowKolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, 2065, Australia.
Raphael ZinnCentre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
Luke T MilhamCentre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia.
Christopher W VaughanKolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, Sydney, 2065, Australia.
Bryce VisselCentre for Neuroscience and Regenerative Medicine (CNRM), Faculty of Science, University of Technology Sydney, PO Box 123 Broadway, Sydney, NSW, 2007, Australia. bryce.vissel@uts.edu.au.
St Vincents Institute of Medical Research · AUThe University of Sydney · AUUniversity of Technology Sydney · AUMacquarie University · AUMiddlemore Hospital · NZRoyal North Shore Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium (Ca

Indexed as

LearningRNA EditingAnimalsBase SequenceBody WeightCA1 Region, HippocampalDendritic SpinesFearLong-Term PotentiationMemory DisordersMiceMotor ActivityNeuronal PlasticityNeuronsReceptors, AMPAReceptors, N-Methyl-D-Aspartateglutamate receptor ionotropic, AMPA 2Receptors, AMPAReceptors, N-Methyl-D-AspartateAlzheimer’s diseaseAMPA receptorsGluA2HippocampusLong term potentiationNeurodegenerationRNA editingSeizuresSynapses

Identifiers

PMID32102661
PMCPMC7045468
OpenAlexW3009576955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.