Evidence map›Paper›PMID 32102520›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

Progesterone Receptor Expression in the Benign Prostatic Hyperplasia and Prostate Cancer Tissues, Relation with Transcription, Growth Factors, Hormone Reception and Components of the AKT/mTOR Signaling Pathway.

Liudmila V Spirina, Irina V Kovaleva, Evgeny A Usynin, Alexey K Goorbunov, Irina V Kondakova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Liudmila V SpirinaLeader Researcher, Laboratory of Tumor Biochemistry, Tomsk National Research Medical Center, Russian Academy of Medical Sciences, Russian Federation.
Irina V KovalevaStudent of Medico-Biological Faculty, Siberian State Medical University, Russian Federation.
Evgeny A UsyninDepartment of Surgical, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Medical Sciences, Russian Federation.
Alexey K GoorbunovDepartment of Surgical, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Medical Sciences, Russian Federation.
Irina V KondakovaLeader Researcher, Laboratory of Tumor Biochemistry, Tomsk National Research Medical Center, Russian Academy of Medical Sciences, Russian Federation.
Siberian State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProgesterone receptor (PR) is a critical regulator in reproductive tissues that controls a variety of cellular processes. The objective of the study was to study the PR expression in patients with benign prostatic hyperplasia and prostate cancers in connection with the transcription, growth factors, AR, ERα, ERβ, and components of the AKT/mTOR signaling pathway expression. MATERIALS AND

methodsNinety-seven patients with prostate pathology were enrolled in the study. Forty-two patients had benign prostatic hyperplasia (BH). Fifty-five patients had locally advanced prostate cancer (PCa). The PSA level and the amount of testosterone in the serum were measured using an ELISA assay. The expression level of NF-κB p65, NF-κB p50, HIF-1, HIF-2, growth factor VEGF, VEGFR2, CAIX, as well as AR, ERα, ERβ, PR, Brn-3α, TRIM16 were quantified by RT-PCR. The protein level of Brn-3α, TRIM16 was detected by Western Blotting.

resultsGrowth in PR expression was observed in PCa tissues compared to BH ones without changes in the clinical and pathological features of the patients. An increase in PR expression was detected in patients with PCa compared to BH. Its mRNA level depended on the expression of AR, Brn-3α, and TRIM16, components of the AKT/mTOR signaling pathway, transcription, and growth factors. An increase in the TRIM16 expression in the PCa tissues was noted in the case of a low PR level. We revealed the growth in PR expression was accompanied by the suppression of the signaling cascade activity, AR, Brn-3α mRNA level, and the enhanced PTEN expression in PCa tissues. The increase in PR expression in PCa led to a decrease in the level of mRNA of NF-κB, HIF-1, VEGF, and VEGFR2.

conclusionIn general, the data indicated the significance of the PR expression in the development of the prostate pathology that affected the cross-talk between the steroid hormone reception and signal transduction. <br />.

Indexed as

AgedBasic Helix-Loop-Helix ProteinsCarbonic Anhydrase IXEndothelial PAS Domain-Containing Protein 1Estrogen Receptor alphaEstrogen Receptor betaHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiddle AgedNF-kappa B p50 SubunitProstatic HyperplasiaProstatic NeoplasmsProto-Oncogene Proteins c-aktReceptors, AndrogenReceptors, ProgesteroneAR protein, humanBasic Helix-Loop-Helix ProteinsCarbonic Anhydrase IXEndothelial PAS Domain-Containing Protein 1ESR1 protein, humanESR2 protein, humanEstrogen Receptor alphaEstrogen Receptor betaHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitKDR protein, humanNF-kappa B p50 SubunitPOU4F1 protein, humanProto-Oncogene Proteins c-aktReceptors, AndrogenReceptors, ProgesteroneRNA, MessengerTOR Serine-Threonine KinasesTranscription Factor Brn-3ATranscription Factor RelATRIM16 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2VEGFA protein, humanAKT/mTOR signaling pathway componentsbenign prostatic hyperplasiaprogesterone receptor (PR)Prostate Cancertranscription and growth factors

Identifiers

PMID32102520
PMCPMC7332139
OpenAlexW3008855303

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.