Evidence map›Paper›PMID 32102414›Full record

ArticleMolecules (Basel, Switzerland)2020

Synthesis and Cytotoxic Activity of New Vindoline Derivatives Coupled to Natural and Synthetic Pharmacophores.

András Keglevich, Leonetta Dányi, Alexandra Rieder, Dorottya Horváth, Áron Szigetvári, Miklós Dékány, Csaba Szántay, Ahmed Dhahir Latif, Attila Hunyadi, István Zupkó and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Novel Piperazine Derivatives of Vindoline as Anticancer Agents.International journal of molecular sciences · 2024
    Article
  2. Article
  3. Review
  4. Article
  5. Piperazine skeleton in the structural modification of natural products: a review.Journal of enzyme inhibition and medicinal chemistry · 2021
    Review
  6. Addition of Vindoline toMolecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

András KeglevichDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellért tér 4., Hungary.
Leonetta DányiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellért tér 4., Hungary.
Alexandra RiederDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellért tér 4., Hungary.
Dorottya HorváthDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellért tér 4., Hungary.
Áron SzigetváriSpectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest 10, P. O. Box 27, Hungary.
Miklós DékánySpectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest 10, P. O. Box 27, Hungary.
Csaba SzántaySpectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest 10, P. O. Box 27, Hungary.
Ahmed Dhahir LatifInstitute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Eötvös u. 6., Hungary.
Attila HunyadiInstitute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Eötvös u. 6., Hungary.
István ZupkóDepartment of Pharmacodynamics and Biopharmacy, Interdisciplinary Excellence Centre, University of Szeged, H-6720 Szeged, Eötvös u. 6., Hungary.
Péter KeglevichDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellért tér 4., Hungary.
László HazaiDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellért tér 4., Hungary.
Budapest University of Technology and Economics · HUGedeon Richter (Hungary) · HUUniversity of Szeged · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New

Indexed as

Amino AcidsAntineoplastic Agents, PhytogenicCell Line, TumorCell SurvivalChemistry Techniques, SyntheticCytotoxinsDose-Response Relationship, DrugHeLa CellsHumansInhibitory Concentration 50MCF-7 CellsMolecular StructureMorpholinesPiperazinesStructure-Activity RelationshipTriazolesAmino AcidsAntineoplastic Agents, PhytogenicCytotoxinsmorpholineMorpholinesPiperazinesTriazolesVinblastinevindolineanticancer drugsIC50 valuesorganic synthesispharmacophoresVinca alkaloidsvindoline

Identifiers

PMID32102414
PMCPMC7070384
OpenAlexW3008732928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.