Evidence map›Paper›PMID 32102392›Full record

ReviewInternational journal of molecular sciences2020

Emerging Potential of Exosomes in Regenerative Medicine for Temporomandibular Joint Osteoarthritis.

Yeon-Hee Lee, Hee-Kyung Park, Q-Schick Auh, Haram Nah, Jae Seo Lee, Ho-Jin Moon, Dong Nyoung Heo, In San Kim, Il Keun Kwon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yeon-Hee LeeDepartment of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, #26 Kyunghee-daero, Dongdaemun-gu, Seoul 02447, Korea.ORCID 0000-0001-7323-0411
Hee-Kyung ParkDepartment of Oral Medicine and Oral Diagnosis, Dental Research Institute, Seoul National UniversitySchool of Dentistry, Seoul 03080, Korea.
Q-Schick AuhDepartment of Orofacial Pain and Oral Medicine, Kyung Hee University Dental Hospital, #26 Kyunghee-daero, Dongdaemun-gu, Seoul 02447, Korea.
Haram NahDepartment of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Jae Seo LeeDepartment of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Ho-Jin MoonDepartment of Dental Materials, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.
Dong Nyoung HeoDepartment of Dental Materials, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.
In San KimCenter for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST),Seoul 02792, Korea.
Il Keun KwonDepartment of Dental Materials, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.

Funding

Il Keun Kwon 2017M3A9E4048170
6 · The paper itself

Abstract

Exosomes are nanosized vesicles (30-140 nm) of endocytic origin that play important roles in regenerative medicine. They are derived from cell membranes during endocytic internalization and stabilize in biological fluids such as blood and synovia. Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, which, in addition to chronic pain, is characterized by progressive cartilage breakdown, condylar bone remodeling, and synovitis. However, traditional clinical treatments have limited symptom- and structure-modifying effects to restore damaged cartilage and other TMJ tissues. This is due to the limited self-healing capacity of condylar cartilage. Recently, stem-cell-derived exosomes have been studied as an alternative therapeutic approach to tissue repair and regeneration. It is known that trophic regulation of mesenchymal stem cells (MSCs) has anti-inflammatory and immunomodulatory effects under pathological conditions, and research on MSC-derived exosomes is rapidly accumulating. MSC-derived exosomes mimic the major therapeutic effects of MSCs. They affect the activity of immune effector cells and possess multilineage differentiation potential, including chondrogenic and osteogenic differentiation. Furthermore, exosomes are capable of regenerating cartilage or osseous compartments and restoring injured tissues and can treat dysfunction and pain caused by TMJ OA. In this review, we looked at the uniqueness of TMJ, the pathogenesis of TMJ OA, and the potential role of MSC-derived exosomes for TMJ cartilage and bone regeneration.

Indexed as

RegenerationAnimalsExosomesHumansMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteoarthritisOsteogenesisRegenerative MedicineTemporomandibular Jointexosomemesenchymal stem cellosteoarthritisosteochondral regenerationregenerative medicinetemporomandibular joint

Identifiers

PMID32102392
PMCPMC7073204

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.