ArticleInternational journal of molecular sciences2020
The Administration of 4-Hexylresorcinol Accelerates Orthodontic Tooth Movement and Increases the Expression Level of Bone Turnover Markers in Ovariectomized Rats.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Age-related alveolar bone maladaptation in adult orthodontics: finding new ways out.International journal of oral science · 2024Review
- Therapeutic Potential of 4-Hexylresorcinol in Preserving Testicular Function in Streptozotocin-Induced Diabetic Rats.International journal of molecular sciences · 2024Article
- Effects of 4-hexylresorcinol on facial skeletal development in growing rats: Considerations for diabetes.Korean journal of orthodontics · 2023Article
- Relevant Properties and Potential Applications of Sericin in Bone Regeneration.Current issues in molecular biology · 2023Review
- Effect of feeding bioactive compounds identified from plant extracts (4-hexylresorcinol, 7-hydroxycoumarin, and gamma-octalactone) on the productivity and quality of broiler meat.Veterinary world · 2022Article
- Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model.Head & face medicine · 2022Article
- Alveolar bone response distal to applied orthodontic forces in ovariectomized rats.Journal of musculoskeletal & neuronal interactions · 2022Article
- 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing.Maxillofacial plastic and reconstructive surgery · 2022Review
- 4-Hexylresorcinol inhibits osteoclastogenesis by suppressing the NF-κB signaling pathway and reverses bone loss in ovariectomized mice.Experimental and therapeutic medicine · 2021Article
- 4-Hexylresorcinol-in duced angiogenesis potential in human endothelial cells.Maxillofacial plastic and reconstructive surgery · 2020Article
- Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Surgical methods for accelerating orthodontic tooth movement are limited by possible damage to the tooth root and patient discomfort. 4-Hexylresorcinol (4HR) has been shown to increase bone remodeling and may potentially facilitate tooth movement. This study investigated the (1) effect of 4HR administration on osteoblast-like cells and (2) effect of 4HR administration on tooth movement in ovariectomized rats. Saos-2 cells were treated with either 4HR or solvent (control). Protein expression levels were investigated 2, 8, and 24 h after treatment. Thirty ovariectomized Sprague-Dawley rats were divided into two experimental groups (A and B) and one control group. After installation of an orthodontic tooth movement device, groups A and B received subcutaneous weekly injections of 4HR (1.28 and 128 mg/kg). Micro-computerized tomography and histological analyses were performed after 2 weeks of tooth movement. The application of 4HR elevated expression of osteogenic markers in Saos-2 cells. Movement of the first molars was significantly greater in rats administered 4HR. Furthermore, the expression of bone morphogenic protein-2, receptor activator of nuclear factor kappa-B ligand, osteocalcin, and tartrate-resistant acid phosphatase were increased after 4HR administration. 4HR application demonstrated increased expression of osteogenic markers in Saos-2 cells and accelerated orthodontic tooth movement in rats.
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Registered trials
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