Evidence map›Paper›PMID 32102184›Full record

Trial reportNutrients2020

Hemoglobin A1c Levels Modify Associations between Dietary Acid Load and Breast Cancer Recurrence.

Tianying Wu, Fang-Chi Hsu, Shunran Wang, David Luong, John P Pierce

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tianying WuDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA 92182, USA.ORCID 0000-0003-1679-3511
Fang-Chi HsuDepartment of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Shunran WangDepartment of Mathematics and Statistics, College of Science, San Diego State University, San Diego, CA 92182, USA.
David LuongDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA 92182, USA.
John P PierceMorres Cancer Center, University of California at San Diego School of Medicine, San Diego, CA 92093, USA.
San Diego State University · USUniversity of California San Diego · USWake Forest University · US

Funding

RCT OF PLANT-BASED DIET IN BREAST CANCER RECURRENCER01CA069375 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, JOHN P · 1998 to 2007
$25.5M
california tobacco-related disease program T30IP0998NCI NIH HHS CA 69375
6 · The paper itself

Abstract

backgroundMetabolic acidosis promotes cancer metastasis. No prospective studies have examined the association between dietary acid load and breast cancer recurrence among breast cancer survivors, who are susceptible to metabolic acidosis. Hyperglycemia promotes cancer progression and acid formation; however, researchers have not examined whether hyperglycemia can modify the association between dietary acid load and breast cancer recurrence.

methodsWe studied 3081 early-stage breast cancer survivors enrolled in the Women's Healthy Eating and Living study who provided dietary information through 24-h recalls at baseline and during follow-up and had measurements of hemoglobin A1c (HbA1c) at baseline. We assessed dietary acid load using two common dietary acid load scores, potential renal acid load (PRAL) score and net endogenous acid production (NEAP) score.

resultsAfter an average of 7.3 years of follow-up, dietary acid load was positively associated with recurrence when baseline HbA1c levels were ≥ 5.6% (median level) and ≥5.7% (pre-diabetic cut-point). In the stratum with HbA1c ≥ 5.6%, comparing the highest to the lowest quartile of dietary acid load, the multivariable-adjusted hazard ratio was 2.15 (95% confidence interval [CI] 1.34-3.48) for PRAL and was 2.31 (95% CI 1.42-3.74) for NEAP. No associations were observed in the stratum with HbA1c levels were <5.6%. P-values for interactions were 0.01 for PRAL and 0.05 for NEAP.

conclusionsOur study demonstrated for the first time that even at or above normal to high HbA1c levels, dietary acid load was associated with increased risk of breast cancer recurrence among breast cancer survivors. IMPACTS: Our study provides strong evidence for developing specific dietary acid load guidelines based on HbA1c levels.

Indexed as

DietAcidsBreast NeoplasmsCancer SurvivorsCohort StudiesFemaleGlycated HemoglobinHumansKidneyMultivariate AnalysisNeoplasm Recurrence, LocalRisk FactorsAcidsGlycated Hemoglobincancer recurrencecancer survivorsDietary acid load

Identifiers

PMID32102184
PMCPMC7071352
OpenAlexW3007417877

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.