ReviewMolecules (Basel, Switzerland)2020
Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 196 citations in OpenAlex.
- Toxicological Assessment and Physiological Responses to Dichloro-Octylisothiazolinone and Octylisothiazolinone in Zebrafish Larvae.Journal of applied toxicology : JAT · 2026Article
- Integrating multi-omics data with network modeling to characterizeJournal of bacteriology · 2026Article
- Marine antifouling biocide 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one disrupts sediment microbiome structure and function: insights from absolute quantification and enzyme activity dynamics.Applied and environmental microbiology · 2026Article
- Development of a Generic Analysis Method for Isothiazolinones in Consumer Products Prompted by Increased Sensitisation to Benzisothiazolinone.Contact dermatitis · 2026Article
- A plasmid-encoded detoxification system contributing to the survival ofApplied and environmental microbiology · 2026Article
- Fungal Communities Associated with Wooden Coffins in a Prehistoric Burial Cave.Journal of fungi (Basel, Switzerland) · 2026Article
- High-throughput antimicrobial efficacy tests on a 384PillarPlate.World journal of microbiology & biotechnology · 2026Article
- Nanostructured Carbon and Gold Screen-Printed Electrodes for Sensitive Detection of Benzisothiazolinone in Environmental Water Samples.Sensors (Basel, Switzerland) · 2026Article
- Procoagulant Effects of Isothiazolinone Biocides, Benzisothiazolinone and Octylisothiazolinone in Platelets.Toxics · 2026Article
- Laboratory and field performance of 2-(thiocyanomethylthio)benzothiazole against fast-growing nontuberculous mycobacteria found in metalworking fluid.Journal of industrial microbiology & biotechnology · 2026Article
- Octylisothiazolinone-A New Sensitizer in Over-Ear Headphones.Contact dermatitis · 2026Article
- Towards Portable One-Drop Voltammetry with Doped Screen-Printed Electrodes to Control Preservatives: A New Tool for Diuron and Isoproturon in the Paint Industry.Sensors (Basel, Switzerland) · 2025Article
- Assessment of airborne and surface microbes on leather cultural relics in museums of arid regions represented by xinjiang, China.Scientific reports · 2025Article
- Biocide-Containing Facades Alter Culture-Based Bacterial and Fungal Community Composition and Resistance Patterns to Octylisothiazolinone.Microorganisms · 2025Article
- Drenched Pages: A Primer on Wet Books.Biology · 2025Review
- Development of image analysis tool to evaluate Langerhans cell migration after exposure to isothiazolinones.Archives of toxicology · 2025Article
- Encapsulated biocides in facade materials impact leaching and UV stability, resulting in lower aquatic toxicity of the eluates.Environmental science and pollution research international · 2025Article
- Mesoporous silica and vegetal extracts combined as sustainable stone heritage protection against biodeterioration.Applied microbiology and biotechnology · 2025Article
- Antibacterial Activity of Eucalyptus Essential Oils in Both Culture Media and Coated Materials.International journal of microbiology · 2025Article
- The skin allergy risk assessment-integrated chemical environment (SARA-ICE) defined approach to derive points of departure for skin sensitization.Current research in toxicology · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of isothiazole and of compounds containing the isothiazole nucleus has been growing over the last few years. Isothiazolinones are used in cosmetic and as chemical additives for occupational and industrial usage due to their bacteriostatic and fungiostatic activity. Despite their effectiveness as biocides, isothiazolinones are strong sensitizers, producing skin irritations and allergies and may pose ecotoxicological hazards. Therefore, their use is restricted by EU legislation. Considering the relevance and importance of isothiazolinone biocides, the present review describes the state-of-the-art knowledge regarding their synthesis, antibacterial components, toxicity (including structure-activity-toxicity relationships) outlines, and (photo)chemical stability. Due to the increasing prevalence and impact of isothiazolinones in consumer's health, analytical methods for the identification and determination of this type of biocides were also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.