ArticleCell reports2020
Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
42 citing papers in PubMed, 70 citations in OpenAlex.
- Visceral leishmaniasis: an integrated review of resistance mechanisms, host immunometabolism, and next generation therapeutics.Inflammopharmacology · 2026Review
- Lymphocyte-mediated immune responses to Leishmania infection.Nature reviews. Immunology · 2026Review
- A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis.iScience · 2026Article
- Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden.Advanced healthcare materials · 2026Article
- Human sand fly challenge elicits saliva-specific innate and type 1-polarized immunity that promotes Leishmania killing.Communications biology · 2026Article
- Sex in Immune Cells and Parasitic Diseases - A Complex Relationship.Immunological reviews · 2026Review
- A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis.bioRxiv : the preprint server for biology · 2025Article
- Persistent myeloid cell reprogramming despite miltefosine treatment in leishmania-infected macaques.iScience · 2025Article
- Leishmaniasis.Nature reviews. Disease primers · 2025Review
- Human sand fly challenge elicits saliva-specific innate and TbioRxiv : the preprint server for biology · 2025Article
- Vertical transmission of Leishmania donovani with placental degeneration in the pregnant mouse model of visceral leishmaniasis.PLoS neglected tropical diseases · 2025Article
- Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice.Nature communications · 2025Article
- Innate biosignature of treatment failure in human cutaneous leishmaniasis.Nature communications · 2025Article
- Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis.Nature communications · 2025Article
- Downregulation of IRF7-mediated type-I interferon response by LmCenNPJ vaccines · 2024Article
- Silver and gold nanoparticles as a novel approach to fight Sarcoptic mange in rabbits.Scientific reports · 2024Article
- Innate biosignature of treatment failure in human cutaneous leishmaniasis.Research square · 2024Article
- IFN-λ3 is induced byInfection and immunity · 2024Article
- Altered IL-7 signaling in CD4+ T cells from patients with visceral leishmaniasis.PLoS neglected tropical diseases · 2024Article
- A parasite odyssey: An RNA virus concealed inVirus evolution · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 8 institutions in 5 countries.
Rajiv KumarCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India; Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India. Electronic address: rajiv082@yahoo.com.
Patrick T BunnQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Griffith University, Institute of Glycomics, Gold Coast, QLD, Australia.
Siddharth Sankar SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Susanna S NgQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Griffith University, School of Natural Sciences, Nathan, QLD, Australia.
Marcela Montes de OcaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Fabian De Labastida RiveraQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Shashi Bhushan ChauhanDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Neetu SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Rebecca J FaleiroQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Chelsea L EdwardsQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; University of Queensland, School of Medicine, Brisbane, QLD Australia.
Teija C M FrameQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Meru SheelQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; National Centre for Epidemiology and Population Health, Research School of Population Health, College of Health and Medicine, The Australian National University, Canberra, ACT, Australia.
Rebecca J AustinQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Steven W LaneQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Tobias BaldQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Mark J SmythQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Geoffrey R HillClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Shannon E BestQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Ashraful HaqueQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Dillon CorvinoQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nic WaddellQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Lambross KoufariotisQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Pamela MukhopadhayQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Madhukar RaiDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Jaya ChakravartyDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Om Prakash SinghDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
David SacksNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Susanne NylenDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Jude UzonnaDepartment of Immunology, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Shyam SundarDepartment of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.
Christian R EngwerdaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. Electronic address: chrise@qimr.edu.au.
QIMR Berghofer Medical Research Institute · AUInstitute of Medical Sciences · INAustralian National University · AUBanaras Hindu University · INFred Hutch Cancer Center · USKarolinska Institutet · SENational Institute of Allergy and Infectious Diseases · USUniversity of Manitoba · CA
Funding
IMMUNE REGULATION AND VACCINE DEVELOPMENT IN LEISHMANIASISZIAAI000494 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SACKS, DAVID · 2009 to 2025
$11.8MVisceral Leishmaniasis in Bihar State, IndiaP50AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2007 to 2016
$6.4MVisceral Leishmaniasis in Bihar State, IndiaU19AI074321 · NIAID · BANARAS HINDU UNIVERSITY · PI SUNDAR, SHYAM · 2017 to 2021
$2.8MNIAID NIH HHS P50 AI074321NIAID NIH HHS U19 AI074321
Abstract
Type I interferons (IFNs) play critical roles in anti-viral and anti-tumor immunity. However, they also suppress protective immune responses in some infectious diseases. Here, we identify type I IFNs as major upstream regulators of CD4
Indexed as
Amphotericin BAnimalsCD4-Positive T-LymphocytesCytokinesDendritic CellsEpitopesHumansImmunityInflammationInterferon-gammaInterferon Type ILeishmaniasis, VisceralMice, Inbred C57BLNitrilesParasitesPyrazolesAmphotericin BCytokinesEpitopesIfnar1 protein, mouseInterferon-gammaInterferon Type Iliposomal amphotericin BNitrilesPyrazolesPyrimidinesReceptor, Interferon alpha-betaruxolitinibCD4(+) T cellstype I interferonsvisceral leishmaniasis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.