Evidence map›Paper›PMID 32101723›Full record

ReviewTrends in cancer2020

The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View.

Joao B Xavier, Vincent B Young, Joseph Skufca, Fiona Ginty, Traci Testerman, Alexander T Pearson, Paul Macklin, Amir Mitchell, Ilya Shmulevich, Lei Xie and 20 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Alterations in the Duodenal Fluid Microbiome of Patients With Pancreatic Cancer.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Trial
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  12. The multi-kingdom cancer microbiome.Nature microbiology · 2025
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76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Joao B XavierProgram for Computational and Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: xavierj@mskcc.org.
Vincent B YoungDepartment of Internal Medicine, Division of Infectious Diseases, The University of Michigan Medical School, Ann Arbor, MI, USA.
Joseph SkufcaDepartment of Mathematics, Clarkson University, Potsdam, NY, USA.
Fiona GintyGE Research, Niskayuna, NY, USA.
Traci TestermanDepartment of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, USA.
Alexander T PearsonSection of Hematology/Oncology, Department of Medicine, Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, IL, USA.
Paul MacklinIntelligent Systems Engineering, Indiana University, Bloomington, IN, USA.
Amir MitchellProgram in Systems Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Ilya ShmulevichInstitute for Systems Biology, Seattle, WA, USA.
Lei XieHunter College, Department of Computer Science, New York, NY, USA.
J Gregory CaporasoCenter for Applied Microbiome Science, Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
Keith A CrandallComputational Biology Institute, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Nicole L SimoneSidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Filipa Godoy-VitorinoDepartment of Microbiology and Medical Zoology, School of Medicine, University of Puerto Rico, San Juan, Puerto Rico.
Timothy J GriffinDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Katrine L WhitesonDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.
Heather H GustafsonSeattle Children's Research Institute, Ben Towne Center for Childhood Cancer Research, Seattle, WA, USA.
Daniel J SladeDepartment of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Thomas M SchmidtUniversity of Michigan, Ann Arbor, MI, USA.
Marina R S Walther-AntonioDepartment of Surgery, Department of Obstetrics and Gynecology, and Microbiome Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
Tal KoremDepartment of Systems Biology, Columbia University, New York, NY, USA.
Bobbie-Jo M Webb-RobertsonBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Mark P StyczynskiSchool of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
W Evan JohnsonDivision of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
Christian JobinDepartments of Medicine, Anatomy, and Cell Biology, and of Infectious Diseases and Immunology, University of Florida, Gainesville, FL, USA.
Jason M RidlonDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Andrew Y KohUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Michael YuToyota Technological Institute at Chicago, Chicago, IL, USA.
Libusha KellyAlbert Einstein College of Medicine, Bronx, NY, USA.
Jennifer A WargoThe University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
Institutional Career Development CoreKL2TR002379 · NCATS · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2017 to 2026
$14.9M
Tumor-specific T cell state dynamics and heterogeneity in early tumorigenesisU54CA209975 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LESLIE, CHRISTINA S, RUDENSKY, ALEXANDER Y · 2016 to 2021
$11.8M
Systems Modeling of Tumor Heterogeneity and Therapy Response in Colorectal CancerR01CA208179 · NCI · GENERAL ELECTRIC GLOBAL RESEARCH CTR · PI GINTY, FIONA · 2017 to 2021
$3.5M
Diet Modification to Augment Radiation for Breast Cancer Brain MetastasesR01CA227479 · NCI · THOMAS JEFFERSON UNIVERSITY · PI SIMONE, NICOLE L · 2018 to 2022
$2.0M
NCATS NIH HHS KL2 TR002379NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA208179NCI NIH HHS R01 CA227479NCI NIH HHS U54 CA209975NCRR NIH HHS M01 RR000585
6 · The paper itself

Abstract

The collection of microbes that live in and on the human body - the human microbiome - can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell-cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology - a systems biology approach.

Indexed as

MicrobiotaAnalgesics, OpioidAnimalsBacteriaCentral Nervous SystemDrug SynergismEnvironmental MicrobiologyGastritisGastrointestinal MicrobiomeHelicobacter InfectionsHost-Pathogen InteractionsHumansImmunotherapyMiceNeoplasmsOncogenic VirusesAnalgesics, Opioid

Identifiers

PMID32101723
PMCPMC7098063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.