ReviewTrends in neurosciences2020
Early Adversity and Critical Periods: Neurodevelopmental Consequences of Violating the Expectable Environment.
Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 265 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
265 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Adverse childhood experiences and resting state functional connectivity of the triple brain network: a meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Adverse childhood experiences and cognitive outcomes among older adults in low-income and middle-income countries: a systematic review.BMJ open · 2026Pooled it
- Sensitive periods to social adversity in immune and metabolic development: A systematic review.Psychoneuroendocrinology · 2025Pooled it
- Electroencephalogram activity related to psychopathological and neuropsychological symptoms in institutionalised minors: a systematic review.Acta neuropsychiatrica · 2025Pooled it
- Sensitive periods in development and risk for psychiatric disorders and related endpoints: a systematic review of child maltreatment findings.The lancet. Psychiatry · 2022Pooled it
- Early psychosocial deprivation alters the refinement of neural dynamics across adolescence.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Effects of Cooking with Liquefied Petroleum Gas or Biomass Fuels on Neurodevelopmental Outcomes in Preschool-Age Children Living in Puno, Peru.Environmental health perspectives · 2025Trial
- Evaluation of a community health worker home visit intervention to improve child development in South Africa: A cluster-randomized controlled trial.PLoS medicine · 2023Trial
- Identifying differential interactions of potentially traumatic experiences with genetic risk for posttraumatic stress disorder.European journal of psychotraumatology · 2026Article
- Least Equal When Most Teachable: The Biodevelopmental Learning Opportunities and Outcomes Model of Gender Differences in Sexuality.Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc · 2026Review
- Developmental Care in the Early Years in Pediatric Intensive Care Patients as a Strategy to Mitigate Pediatric Post-Intensive-Care Syndrome: A Narrative Review.Journal of intensive care medicine · 2026Review
- Promotion of long-term health in early life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Micro- and nanoplastics alter electrophysiological brain patterns and reshape human neurodevelopmental trajectories.bioRxiv : the preprint server for biology · 2026Article
- Mapping the landscape of early childhood development services: a global scoping review.BMJ open · 2026Article
- The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults.BMC psychiatry · 2026Article
- The Revised ACE Pyramid: A Contemporary Framework for Understanding Childhood Adversity and Advancing Toxic Stress Prevention and Healing.Children (Basel, Switzerland) · 2026Article
- The Critical Period Microbiota Shape Brain Plasticity.Research square · 2026Article
- Loss of pleasure (Anhedonia): A sex-dependent, cross-species consequence of unpredictable signals to the perinatal brain.Neurobiology of stress · 2026Article
- Types of Screen Time and Developmental Outcomes Among Children Aged 0-6 Years in Thailand: A Cross-Sectional Study.Child: care, health and development · 2026Article
- Early Adversity Imprints Multisystem Biological Aging: A Longitudinal Study of Adversity Dimensions and Aging Phenotypes Across Adolescence.Biological psychiatry global open science · 2026Article
205 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is now widely recognized that children exposed to adverse life events in the first years of life are at increased risk for a variety of neural, behavioral, and psychological sequelae. As we discuss in this paper, adverse events represent a violation of the expectable environment. If such violations occur during a critical period of brain development, the detrimental effects of early adversity are likely to be long lasting. Here we discuss the various ways adversity becomes neurobiologically embedded, and how the timing of such adversity plays an important role in determining outcomes. We conclude our paper by offering recommendations for how to elucidate the neural mechanisms responsible for the behavioral sequelae and how best to model the effects of early adversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.