Evidence map›Paper›PMID 32101705›Full record

ArticleCell host & microbe2020

Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip.

Justin E Silpe, Andrew A Bridges, Xiuliang Huang, Daniela R Coronado, Olivia P Duddy, Bonnie L Bassler

Open access · bronzeAbstract read
In one paragraph

Article in Cell host & microbe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 44 citations in OpenAlex.

  1. mBio · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Natural Silencing of Quorum-Sensing Activity ProtectsbioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Genome Analysis of an Enterococcal Prophage, Entfac.MY.Avicenna journal of medical biotechnology
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Justin E SilpeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Andrew A BridgesDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Xiuliang HuangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Daniela R CoronadoDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Olivia P DuddyDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Bonnie L BasslerDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: bbassler@princeton.edu.
Howard Hughes Medical Institute · USPrinceton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Intra- and Inter- Species Communication in BacteriaR37GM065859 · NIGMS · PRINCETON UNIVERSITY · PI BASSLER, BONNIE L · 2016 to 2025
$3.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R37 GM065859NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Quorum sensing is a process of chemical communication that bacteria use to track cell density and coordinate gene expression across a population. Bacteria-infecting viruses, called phages, can encode quorum-sensing components that enable them to integrate host cell density information into the lysis-lysogeny decision. Vibriophage VP882 is one such phage, and activation of its quorum-sensing pathway leads to the production of an antirepressor called Qtip. Qtip interferes with the prophage repressor (cI

Indexed as

BacteriophagesDNA-Binding ProteinsEscherichia coliGene Expression Regulation, BacterialGenes, ViralLysogenyProphagesQuorum SensingRepressor ProteinsViral ProteinsViral Regulatory and Accessory ProteinsDNA-Binding Proteinsphage repressor proteinsRepressor ProteinsViral ProteinsViral Regulatory and Accessory ProteinsantirepressorcI repressorlysis-lysogenyphageQtipquorum sensing

Identifiers

PMID32101705
PMCPMC7148176
OpenAlexW3008473354

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.