ArticlePloS one2020
First Indian report on genome-wide comparison of multidrug-resistant Escherichia coli from blood stream infections.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Carbapenemase-producing carbapenem-resistant Enterobacterales in surgical intensive care unit patients in a tertiary hospital in India.Nature communications · 2026Article
- Whole genome analysis of a multidrug-resistant blaBMC microbiology · 2026Article
- Genomic analysis of ST117, 155, 1011, 167, 744, and 17391 in poultry-associated multidrug resistant Escherichia coli isolates from India.Scientific reports · 2026Article
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- Hidden carriers: multidrug-resistant bacteria in hedgehogs from a wildlife rescue centre.Frontiers in veterinary science · 2026Article
- Predominance of antimicrobial resistance genes and high-risk clones among Gram negatives from clinical sources in Accra-Ghana.PloS one · 2026Article
- Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.Scientific reports · 2025Article
- Ceftazidime-avibactam activity againstIranian journal of microbiology · 2025Article
- Prevalence and genomic insights of carbapenem resistant and ESBL producing Multidrug resistant Escherichia coli in urinary tract infections.Scientific reports · 2025Article
- Emergence of Carbapenem-Resistant UropathogenicPathogens (Basel, Switzerland) · 2024Article
- Clinically relevant mutations in regulatory regions of metabolic genes facilitate early adaptation to ciprofloxacin in Escherichia coli.Nucleic acids research · 2024Article
- The Prevalence of Multidrug-ResistantIndian journal of microbiology · 2024Article
- Unveiling the genetic architecture and transmission dynamics of a novel multidrug-resistant plasmid harboring blaBMC microbiology · 2024Article
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- Review
- Article
- Nitrofurantoin resistance as an indicator for multidrug resistance: an assessment ofJAC-antimicrobial resistance · 2023Article
- A Decade-Long Evaluation of Neonatal Septicaemic Escherichia coli: Clonal Lineages, Genomes, and New Delhi Metallo-Beta-Lactamase Variants.Microbiology spectrum · 2023Article
- Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundMultidrug-resistant (MDR) E. coli with extended-spectrum β-lactamases (ESBLs) is becoming endemic in health care settings around the world. Baseline data on virulence and antimicrobial resistance (AMR) of specific lineages of E. coli circulating in developing countries like India is currently lacking.
methodsWhole-genome sequencing was performed for 60 MDR E. coli isolates. The analysis was performed at single nucleotide polymorphism (SNP) level resolution to identify the presence of their virulence and AMR genes.
resultsGenome comparison revealed the presence of ST-131 global MDR and ST410 as emerging-MDR clades of E. coli in India. AMR gene profile for cephalosporin and carbapenem resistance differed between the clades. Genotypes blaCTX-M-15 and blaNDM-5 were common among cephalosporinases and carbapenemases, respectively. For aminoglycoside resistance, rmtB was positive for 31.7% of the isolates, of which 95% were co-harboring carbapenemases. In addition, the FimH types and virulence gene profile positively correlated with the SNP based phylogeny, and also revealed the evolution of MDR clones among the study population with temporal accumulation of SNPs. The predominant clone was ST167 (blaNDM lineage) followed by ST405 (global clone ST131 equivalent) and ST410 (fast spreading high risk clone).
conclusionsThis is the first report on the whole genome analysis of MDR E. coli lineages circulating in India. Data from this study will provide public health agencies with baseline information on AMR and virulent genes in pathogenic E. coli in the region.
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