SynthesisQJM : monthly journal of the Association of Physicians2020
Incidence and mortality of acute kidney injury in patients undergoing hematopoietic stem cell transplantation: a systematic review and meta-analysis.
Synthesis in QJM : monthly journal of the Association of Physicians, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Paraneoplastic Minimal Change Disease Signaling Post-Transplant AML Relapse: Two Cases and a Literature Review.Current oncology (Toronto, Ont.) · 2026Review
- Renal resistive index and shear wave elastography in assessment of kidney function after allogeneic hematopoietic cell transplantation: a pilot prospective observational study.Polish journal of radiology · 2026Article
- Article
- Kidney function after nonmyeloablative hematopoietic cell transplant for sickle cell disease.Bone marrow transplantation · 2025Article
- Markers of Kidney Injury: Proenkephalin A and Uromodulin, but Not Dickkopf-3, Are Elevated in Patients After Hematopoietic Stem Cell Transplantation.International journal of molecular sciences · 2025Article
- Risk Factors and Long-Term Outcomes of Acute Kidney Disease in Hematopoietic Stem Cell Transplant-Cohort Study.Cancers · 2025Article
- Risk of and Mortality After Acute Kidney Injury Following Cancer Treatment: A Cohort Study.Cancer medicine · 2025Article
- Kidney Disease and Hematopoietic Stem Cell Transplantation.Kidney360 · 2025Review
- Allogeneic Transplantation for Older Adults.Advances in experimental medicine and biology · 2025Review
- Metabolic syndrome and symptom burden in allogeneic hematopoietic stem cell transplantation survivors.Future oncology (London, England) · 2024Article
- Acute kidney injury and risk factors in pediatric patients undergoing hematopoietic stem cell transplantation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Health care costs among patients with hematologic malignancies receiving allogeneic transplants: a US payer perspective.Blood advances · 2024Article
- Acute kidney injury in multiple myeloma patients undergoing autologous hematopoietic stem cell transplant: a cohort study.Journal of nephrology · 2024Article
- Analysis of risk factors for fatal renal complications after allogeneic hematopoietic cell transplantation.Bone marrow transplantation · 2024Article
- Article
- Allogeneic T cells cause acute renal injury after hematopoietic cell transplantation.Blood advances · 2023Article
- Article
- Rationale for the evaluation of renal functional reserve in allogeneic stem cell transplantation candidates: a pilot study.Clinical kidney journal · 2023Article
- Clinico-pathological correlations and outcomes ofClinical kidney journal · 2023Article
- Population Pharmacokinetics of Ganciclovir in Allogeneic Hematopoietic Stem Cell Transplant Patients.Antimicrobial agents and chemotherapy · 2023Observational
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWhile acute kidney injury (AKI) is commonly reported following hematopoietic stem cell transplant (HCT), the incidence and impact of AKI on mortality among patients undergoing HCT are not well described. We conducted this systematic review to assess the incidence and impact of AKI on mortality risk among patients undergoing HCT.
methodsOvid MEDLINE, EMBASE and the Cochrane Databases were searched from database inceptions through August 2019 to identify studies assessing the incidence of AKI and mortality risk among adult patients who developed AKI following HCT. Random-effects and generic inverse variance method of DerSimonian-Laird were used to combine the effect estimates obtained from individual studies.
resultsWe included 36 cohort studies with a total of 5144 patients undergoing HCT. Overall, the pooled estimated incidence of AKI and severe AKI (AKI Stage III) were 55.1% (95% confidence interval (CI) 46.6-63.3%) and 8.3% (95% CI 6.0-11.4%), respectively. The pooled estimated incidence of AKI using contemporary AKI definitions (RIFLE, AKIN and KDIGO criteria) was 49.8% (95% CI 41.6-58.1%). There was no significant correlation between study year and the incidence of AKI (P = 0.12) or severe AKI (P = 0.97). The pooled odds ratios of 3-month mortality and 3-year mortality among patients undergoing HCT with AKI were 3.05 (95% CI 2.07-4.49) and 2.23 (95% CI 1.06-4.73), respectively.
conclusionThe incidence of AKI among patients who undergo HCT remains high, and it has not changed over the years despite advances in medicine. AKI after HCT is associated with increased short- and long-term mortality.
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