Evidence map›Paper›PMID 32101144›Full record

ArticleParticle and fibre toxicology2020

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo.

Sivakumar Murugadoss, Frederic Brassinne, Noham Sebaihi, Jasmine Petry, Stevan M Cokic, Kirsten L Van Landuyt, Lode Godderis, Jan Mast, Dominique Lison, Peter H Hoet and 1 more

Open access · goldAbstract read
In one paragraph

Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 115 citations in OpenAlex.

  1. Article
  2. Review
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  4. The potential adverse human health effects of metal-containing nanoparticles: a scoping review.Journal of occupational medicine and toxicology (London, England) · 2025
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  7. Optimizing Sunscreen Safety: The Impact of TiONanomaterials (Basel, Switzerland) · 2025
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  13. ExploringACS omega · 2024
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  14. Article
  15. Review
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Sivakumar MurugadossLaboratory of Toxicology, Unit of Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000, Leuven, Belgium.
Frederic BrassinneTrace Elements and Nanomaterials, Sciensano, 1180, Uccle, Belgium.
Noham SebaihiNational Standards, FPS Economy, 1000, Brussels, Belgium.
Jasmine PetryNational Standards, FPS Economy, 1000, Brussels, Belgium.
Stevan M CokicDepartment of Oral Health Sciences, KU Leuven, BIOMAT & UZ Leuven (University Hospitals Leuven), Dentistry, Kapucijnenvoer 7, 3000, Leuven, Belgium.
Kirsten L Van LanduytDepartment of Oral Health Sciences, KU Leuven, BIOMAT & UZ Leuven (University Hospitals Leuven), Dentistry, Kapucijnenvoer 7, 3000, Leuven, Belgium.
Lode GodderisLaboratory for Occupational and Environmental Hygiene, Unit of Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000, Leuven, Belgium.
Jan MastTrace Elements and Nanomaterials, Sciensano, 1180, Uccle, Belgium.
Dominique LisonLouvain centre for Toxicology and Applied Pharmacology, Institute of Experimental and Clinical Research, Université catholique de Louvain, 1200, Brussels, Belgium.
Peter H HoetLaboratory of Toxicology, Unit of Environment and Health, Department of Public Health and Primary Care, KU Leuven, 3000, Leuven, Belgium. peter.hoet@kuleuven.be.ORCID 0000-0002-0292-6603
Sybille van den BruleLouvain centre for Toxicology and Applied Pharmacology, Institute of Experimental and Clinical Research, Université catholique de Louvain, 1200, Brussels, Belgium. sybille.vandenbrule@uclouvain.be.
KU Leuven · BESciensano (Belgium) · BEService Public Fédéral Économie · BEUCLouvain · BEUniversitair Ziekenhuis Leuven · BEDepartment of Public Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanoparticle (NP) agglomeration and aggregation on toxicity is poorly understood although it is strongly believed that smaller the size of the NPs greater the toxicity. A toxicologically relevant definition of NMs is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, we assessed the influence of NP agglomeration on their toxicity/biological responses in vitro and in vivo.

resultsWe tested two TiO

conclusionAgglomeration of TiO

Indexed as

DNA DamageAdministration, OralAnimalsBronchoalveolar Lavage FluidCaco-2 CellsCell SurvivalEpithelial CellsFemaleHumansInhalation ExposureMice, Inbred C57BLNanoparticlesParticle SizeSurface PropertiesTHP-1 CellsTitaniumTitaniumtitanium dioxideAgglomeratesBiological responsesNanomaterialsTitanium dioxideToxicity

Identifiers

PMID32101144
PMCPMC7045370
OpenAlexW3012847867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.