Evidence map›Paper›PMID 32100936›Full record

ReviewClinical and translational science2020

Pharmacogenomics in Asian Subpopulations and Impacts on Commonly Prescribed Medications.

Cody Lo, Samantha Nguyen, Christine Yang, Lana Witt, Alice Wen, T Vivian Liao, Jennifer Nguyen, Bryant Lin, Russ B Altman, Latha Palaniappan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical and translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

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  20. Association Between Perioperative Celecoxib, Acetaminophen, and Opioid Consumption After Palate Surgery for Obstructive Sleep Apnea.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cody LoFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Samantha NguyenCollege of Pharmacy, Mercer University, Atlanta, Georgia, USA.
Christine YangSchool of Medicine, Stanford University, Palo Alto, California, USA.
Lana WittSchool of Medicine, Stanford University, Palo Alto, California, USA.
Alice WenSchool of Medicine, Stanford University, Palo Alto, California, USA.
T Vivian LiaoCollege of Pharmacy, Mercer University, Atlanta, Georgia, USA.
Jennifer NguyenCollege of Pharmacy, Mercer University, Atlanta, Georgia, USA.
Bryant LinDivision of Primary Care and Population Health, School of Medicine, Stanford University, Palo Alto, California, USA.
Russ B AltmanDepartment of Biomedical Data Science, Stanford University, Palo Alto, California, USA.
Latha PalaniappanDivision of Primary Care and Population Health, School of Medicine, Stanford University, Palo Alto, California, USA.
Stanford University · USMercer University Health Sciences Center · USUniversity of British Columbia · CA

Funding

Cardiovascular Disease Among Asians and Pacific Islanders (CASPER)R01HL126172 · NHLBI · KAISER FOUNDATION RESEARCH INSTITUTE · PI FORTMANN, STEPHEN PAUL, PALANIAPPAN, LATHA P · 2015 to 2018
$3.0M
META - Mentor, Educate, Train, Advocate: Patient Oriented Researchers in Cardiometabolic DiseaseK24HL150476 · NHLBI · STANFORD UNIVERSITY · PI Latha P Palaniappan · 2020 to 2026
$846k
NHLBI NIH HHS K24 HL150476NHLBI NIH HHS R01 HL126172
6 · The paper itself

Abstract

Asians as a group comprise > 60% the world's population. There is an incredible amount of diversity in Asian and admixed populations that has not been addressed in a pharmacogenetic context. The known pharmacogenetic differences in Asian subgroups generally represent previously known variants that are present at much lower or higher frequencies in Asians compared with other populations. In this review we summarize the main drugs and known genes that appear to have differences in their pharmacogenetic properties in certain Asian populations. Evidence-based guidelines and summary statistics from the US Food and Drug Administration and the Clinical Pharmacogenetics Implementation Consortium were analyzed for ethnic differences in outcomes. Implicated drugs included commonly prescribed drugs such as warfarin, clopidogrel, carbamazepine, and allopurinol. The majority of these associations are due to Asians more commonly being poor metabolizers of cytochrome P450 (CYP) 2C19 and carriers of the human leukocyte antigen (HLA)-B*15:02 allele. The relative risk increase was shown to vary between genes and drugs, but could be > 100-fold higher in Asians. Specifically, there was a 172-fold increased risk of Stevens-Johnson syndrome and toxic epidermal necrolysis with carbamazepine use among HLA-B*15:02 carriers. The effects ranged from relatively benign reactions such as reduced drug efficacy to severe cutaneous skin reactions. These reactions are severe and prevalent enough to warrant pharmacogenetic testing and appropriate changes in dose and medication choice for at-risk populations. Further studies should be done on Asian cohorts to more fully understand pharmacogenetic variants in these populations and to clarify how such differences may influence drug response.

Indexed as

Pharmacogenomic VariantsAnticoagulantsAnticonvulsantsAntidepressive AgentsAntifungal AgentsAntineoplastic AgentsAntiviral AgentsAsian PeopleCytochrome P-450 CYP2C19Global Burden of DiseaseHeterozygoteHLA-B15 AntigenHumansIncidencePharmacogenomic TestingPlatelet Aggregation InhibitorsAnticoagulantsAnticonvulsantsAntidepressive AgentsAntifungal AgentsAntineoplastic AgentsAntiviral AgentsCYP2C19 protein, humanCytochrome P-450 CYP2C19HLA-B*15:02 antigenHLA-B15 AntigenPlatelet Aggregation Inhibitors

Identifiers

PMID32100936
PMCPMC7485947
OpenAlexW3006939649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.