ArticleJournal of clinical laboratory analysis2020
Study on the correlation between hTREC and HPV load and cervical CINI/II/III lesions and cervical cancer.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- HPV integration profiling using nanopore sequencing and association with cervical precancerous lesion.Frontiers in microbiology · 2025Article
- HPV infection status among women of all ages in Jinshan District, Shanghai.The Journal of international medical research · 2024Article
- Development of human papillomavirus and its detection methods (Review).Experimental and therapeutic medicine · 2024Review
- An overview of the role of telomeres and telomerase in pre‑neoplastic lesions (Review).Molecular and clinical oncology · 2023Review
- Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer.African health sciences · 2023Article
- Review
- Study on the correlation between hTREC and HPV load and cervical CINI/II/III lesions and cervical cancer.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the correlation between hTREC and human papillomavirus (HPV) load and cervical intraepithelial neoplasia (CIN) grade II/III lesions and cervical cancer.
methodsA total of 135 patients with cervical lesions of different degrees admitted to our hospital from January 2016 to February 2017 were selected, including CIN I/III 65 cases, grade III 39 cases, and cervical cancer 31 cases. The expression of hTERC gene was detected by fluorescence in situ hybridization (FISH) in three groups, and the HPV load was detected by second-generation hybridization capture (HC II) method, and its relationship with cervical lesion grade was analyzed. Department.
resultsThe positive expression rate of hTERC gene amplification was cervical cancer > CIN I/II lesion > CIN III lesion; the positive expression rate of HPV was cervical cancer > CIN I/II lesion > CIN III lesion. After treatment, the positive rate of hTERC gene amplification and HPV expression decreased significantly within 1 year (P < .05). Spearman's analysis showed that the degree of cervical lesion was positively correlated with hTREC and HPV load (P < .05).
conclusionhTREC and HPV are closely related to the occurrence and development of cervical precancerous lesions and cervical cancer. The abnormal amplification of hTERC gene increases with the grade of cervical lesions. Both of them can be used as auxiliary indicators for early screening, treatment, and prognosis of cervical cancer.
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Registered trials
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