Evidence map›Paper›PMID 32100913›Full record

ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2020

Lack of discreet colocalization of epithelial apoptosis to the atretic precursor in the colon of the Fibroblast growth factor receptor 2IIIb mouse and staining consistent with cellular movement suggest a revised model of atresia formation.

Anna Kowalkowski, Krzysztof M Zaremba, Andrew P Rogers, Olivia R Hoffman, Anne E Turco, Peter F Nichol

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anna KowalkowskiSurgery Department, University of Wisconsin, Madison, Wisconsin, USA.ORCID 0000-0002-1902-7890
Krzysztof M ZarembaSurgery Department, University of Wisconsin, Madison, Wisconsin, USA.
Andrew P RogersSurgery Department, University of Wisconsin, Madison, Wisconsin, USA.
Olivia R HoffmanSurgery Department, University of Wisconsin, Madison, Wisconsin, USA.
Anne E TurcoDepartment of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin, USA.
Peter F NicholSurgery Department, University of Wisconsin, Madison, Wisconsin, USA.
University of Wisconsin System · US

Funding

TRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2M
Developmental origins of prostate-related urinary dysfunction in adult males: TCDD exposure increases prostatic noradrenergic innervation and smooth muscle contractionF31ES030968 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI TURCO, ANNE · 2020 to 2021
$42k
NIDDK NIH HHS T32 DK007665NIEHS NIH HHS F31 ES030968UW-Madison, Surgery Department 233-AAA4927-539790UW-Madison, UW Institute for Clinical and Translational Research (ICTR) 233-AAB8495-539790
6 · The paper itself

Abstract

backgroundColonic atresias in the Fibroblast growth factor receptor 2IIIb (Fgfr2IIIb) mouse model have been attributed to increased epithelial apoptosis and decreased epithelial proliferation at embryonic day (E) 10.5. We therefore hypothesized that these processes would colocalize to the distal colon where atresias occur (atretic precursor) and would be excluded or minimized from the proximal colon and small intestine.

resultsWe observed a global increase in intestinal epithelial apoptosis in Fgfr2IIIb

conclusionsOur observations suggest that alterations in proliferation and apoptosis alone are insufficient to account for intestinal atresias and that these defects may arise from both a failure of distal colonic epithelial cells to develop normally and local disruptions in basal lamina architecture.

Indexed as

ActinsAnimalsApoptosisbeta CateninCadherinsCell ProliferationColonFemaleImmunohistochemistryMaleMiceVimentinActinsbeta CateninCadherinsVimentinbasal laminaE-cadherinembryonic developmentEMTgene expressionlamininmice

Identifiers

PMID32100913
PMCPMC7266729
OpenAlexW3008570449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.