Evidence map›Paper›PMID 32100896›Full record

Observational studyScandinavian journal of medicine & science in sports2020

The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence.

Zhengzheng Huang, Ricardo Fonseca, James E Sharman, Chloe Park, Nish Chaturvedi, Laura D Howe, Alun D Hughes, Martin G Schultz

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scandinavian journal of medicine & science in sports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Zhengzheng HuangMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0000-0002-0196-5109
Ricardo FonsecaMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
James E SharmanMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Chloe ParkDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.
Nish ChaturvediDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.
Laura D HoweMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Alun D HughesDepartment of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.
Martin G SchultzMenzies Institute for Medical Research, University of Tasmania, Hobart, Australia.ORCID https://orcid.org/0000-0003-3458-1811
University of Tasmania · AUMRC Unit for Lifelong Health and Ageing · GBUniversity College London · GBUniversity of Bristol · GB

Funding

British Heart Foundation CS/15/6/31468British Heart Foundation PG/06/145/21955British Heart Foundation PG/06/145 & CS/15/6/31468Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00019/2National Health and Medical Research Council 1104731UK Medical Research Council MC_UU_00011/6UK Medical Research Council MC_UU_12019/1UK Medical Research Council MR/M020894/1University of BristolWellcome Trust 086676Wellcome Trust 086676/7/08/ZWellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

purposeExaggerated exercise blood pressure (BP) is associated with altered cardiac structure and increased cardiovascular risk. Fitness modifies these associations, but the effect in healthy adolescents is unknown. We performed an observational study to determine the influence of fitness on post-exercise BP, and on its relationship with cardiac structure in adolescents.

methods4835 adolescents from the Avon Longitudinal Study of Parents and Children, (15.4 (0.3) years, 49% male) completed a submaximal cycle test. Fitness was estimated as physical work capacity 170 adjusted for lean body mass and post-exercise BP measured immediately posttest. Cardiovascular structure and function, including left ventricular (LV) mass (n = 1589), left atrium (LA) size (n = 1466), cardiac output (CO, n = 1610), and total peripheral resistance (TPR, n = 1610) were measured at rest by echocardiography 2.4 (0.4) years later.

resultsPost-exercise systolic BP increased stepwise by fitness tertile (131.2 mm Hg [130.4, 132.1]; 137.3 mm Hg [136.5, 138.0]; 142.3 mm Hg [141.5, 143.1]). Each 5 mm Hg of post-exercise systolic BP was associated with 2.46 g [1.91, 3.01] greater LV mass, 0.02 cm [0.02, 0.03] greater LA size, and 0.25 g/m

conclusionsPost-exercise systolic BP increased with fitness, which modified its association with cardiac structure. Higher CO, but lower TPR suggests a physiologically adapted cardiovascular system with greater fitness, highlighting the importance of fitness in adolescence.

Indexed as

Blood PressureExercisePhysical FitnessAdolescentEchocardiographyExercise TestFemaleHealthy VolunteersHeartHumansLongitudinal StudiesMaleadolescentALSPACblood pressureexercisefitnessleft ventricle

Identifiers

PMID32100896
PMCPMC7239671
OpenAlexW3006952263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.