Evidence map›Paper›PMID 32100807›Full record

ArticleOrganic & biomolecular chemistry2020

Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates.

Johnathan C Maza, Alexandra V Ramsey, Meire Mehare, Shane W Krska, Craig A Parish, Matthew B Francis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Chemical Conjugation to Less Targeted Proteinogenic Amino Acids.Chembiochem : a European journal of chemical biology · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johnathan C MazaDepartment of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu.ORCID 0000-0003-2898-8770
Alexandra V RamseyDepartment of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu.
Meire MehareDepartment of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu.
Shane W KrskaDiscovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, USA.ORCID 0000-0001-9757-9036
Craig A ParishDiscovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, USA.ORCID 0000-0002-7162-3542
Matthew B FrancisDepartment of Chemistry, University of California, Berkeley, California 94720, USA. mbfrancis@berkeley.edu and Materials Science Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720, USA.ORCID 0000-0003-2837-2538

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

Indexed as

AminesHydrazinesHydrazonesKetonesOxidation-ReductionOximesProlineProteinsPyrococcus furiosusTobacco Mosaic VirusAminesHydrazinesHydrazonesKetonesOximesProlineProteins

Identifiers

PMID32100807
PMCPMC7213020

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.