ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2020
Donation after circulatory determination of death in western Canada: a multicentre study of donor characteristics and critical care practices.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- An Integrative Review on Exploring Organ Donation After Death by Circulatory Criteria in Canada.Progress in transplantation (Aliso Viejo, Calif.) · 2025Review
- Donation Physician Specialists and Missed Organ Donation Opportunities.JAMA network open · 2025Article
- Organ donation after death determination by circulatory criteria: family members' experiences with withdrawal of life-sustaining measures in Canadian intensive care units.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Article
- The History of Donation after Circulatory Death (DCD): Backlash and Boomerang.Neurocritical care · 2024Article
- End-Of-Life Care in the Potential Donor after Circulatory Death: A Systematic Review.The Neurohospitalist · 2023Review
- Practice and challenges for organ donation after medical assistance in dying: A scoping review including the results of the first international roundtable in 2021.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Predicting Time to Death After Withdrawal of Life-Sustaining Measures Using Vital Sign Variability: Derivation and Validation.Critical care explorations · 2022Article
- Premortem anticoagulation timing and dose in donation after circulatory death: multicentre study of associations with graft function.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDonation after circulatory determination of death (DCD) has been performed in Canada since 2006. Numerous aspects of donor management remain controversial.
methodsWe performed a multicentre cohort study involving potential DCD donors in western Canada (2008-2017), as well as recipients of their organs, to describe donor characteristics and critical care practices, and their relation to one-year recipient and graft survival.
resultsThere were 257 patients in four provinces that underwent withdrawal of life-sustaining therapies (WLST) in anticipation of possible DCD. The proportion of patients that died within two hours of WLST ranged from 67% to 88% across provinces (P = 0.06), and was predicted by deeper coma (P = 0.01), loss of pupillary light or corneal reflexes (P = 0.02), and vasopressor use (P = 0.01). There were significant differences between provinces in time intervals from onset of hypotension to death (9-11 min; P = 0.02) and death to vascular cannulation (7-10 min; P < 0.001). There was inconsistency in pre-mortem heparin administration (82-96%; P = 0.03), including timing (before vs after WLST; P < 0.001) and dose (≥ 300 vs < 300 units·kg
conclusionThere is significant variability in critical care DCD practices in western Canada, but this has not resulted in significant differences in recipient or graft survival. Further research is required to guide optimal management of potential DCD donors.
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