Evidence map›Paper›PMID 32100129›Full record

ArticleAMB Express2020

Decreased expression of LRA4, a key gene involved in rhamnose metabolism, caused up-regulated expression of the genes in this pathway and autophagy in Pichia pastoris.

Jian Jiao, Shuai Wang, Hui Tian, Xinxin Xu, Yuhong Zhang, Bo Liu, Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jian JiaoBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China.
Shuai WangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China.
Hui TianBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China.
Xinxin XuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China.
Yuhong ZhangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China.
Bo LiuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China. liubo01@caas.cn.
Wei ZhangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, No.12., Zhongguancun South St., Haidian District, Beijing, 100081, China. zw_bio@caas.cn.

Funding

Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences (CN) Y2019XK19National Natural Science Foundation of China 31671802National Transgenic Major Program 2019ZX08010-004
6 · The paper itself

Abstract

In a previous study, we developed Pichia pastoris GS115m, an engineered strain with decreased expression of one key gene, LRA4, in rhamnose metabolism. P. pastoris GS115m/LacB was subsequently constructed via introducing a β-galactosidase gene, LacB, under the control of rhamnose-inducible P

Indexed as

AutophagyPichia pastorisRhamnose metabolismTranscriptome

Identifiers

PMID32100129
PMCPMC7042458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.