Trial reportOral health & preventive dentistry2020
Does Streptococcus Salivarius Strain M18 Assumption Make Black Stains Disappear in Children?
Trial report in Oral health & preventive dentistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Colonisation of Probiotic Bacterium Streptococcus Salivarius in the Oral Cavity
Assessment of Colonization of Dairy Free Probiotic Bacterium Streptococcus Salivarius From Lozenges to the Oral Cavity
Colonisation Efficacy of Streptococcus Salivarius M18 Toothpaste
Colonisation Efficacy of a Probiotic Chewing Gum.
Colonisation Efficacy of Streptococcus Salivarius M18 Toothpaste
Who cites it
5 citing papers in PubMed.
- Comparison of the cytotoxic and apoptotic effects of mouthwashes containing different active ingredients on human gingival fibroblasts and their antimicrobial efficacy.BMC oral health · 2026Article
- The potential bactericidal effect of oral probiotics on extrinsic black stain-associated bacteria in children: AnJournal of dental sciences · 2025Article
- Review
- Article
- In vitro inhibitory effect of two commercial probiotics on chromogenic actinomycetes.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis randomised controlled study evaluated the effectiveness of an oral probiotic, Streptococcus salivarius M18 (SsM18), in children with black stains (BSs) in order to counteract their reformation. MATERIALS AND
methodsFifty-eight children (aged 4-10 years) presenting with BSs were enrolled. They were randomly divided into two groups: group A (n = 29) included children who were given the test product containing SsM18 once a day for 3 months; group B (n = 29) included children who did not receive any treatment. Before beginning the study, all the children underwent professional removal of BSs. The assessment of BSs was done after 3 months (T1) and after 6 months (T2).
resultsFour patients (1 belonging to group A and 3 to group B) were excluded from the study because they started antibiotic therapy. After 3 months (T1), BSs were detected in 6 of the 28 children (21.2%) from group A and in 13 out of the 26 (50%) children from group B (p < 0.05). After 6 months (T2), BSs were detected in 9 out of the 28 (32.1%) children from group A and in 14 of the 26 (53.8%) children from group B (p > 0.05).
conclusionsBSs formation in children could be prevented by administering S. salivarius M18.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.