ArticleJournal of oral biology and craniofacial research
Role of bone marrow-derived mesenchymal stem cells on the parotid glands of streptozotocin induced diabetes rats.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 18 citations in OpenAlex.
- Effect of locally transplanted bone marrow derived mesenchymal stem cells on the lingual filiform and fungiform papillae of ovariectomized albino rat model.BMC oral health · 2026Article
- The synergetic potential of gold nanoparticles and bone marrow stem cells in regeneration of tongue defects (An experimental study on Rats).Oral and maxillofacial surgery · 2025Article
- Estrogen versus bone marrow mesenchymal stromal cells in the regeneration of the parotid gland in ovariectomized rats.Journal of applied oral science : revista FOB · 2025Article
- Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023Review
- Evaluation of hypoglycemic therapeutics and nutritional supplementation for type 2 diabetes mellitus management: An insight on molecular approaches.Biotechnology letters · 2022Review
- Human dental pulp stem cells attenuate streptozotocin-induced parotid gland injury in rats.Stem cell research & therapy · 2021Article
- Aquaporins in insulin resistance and diabetes: More than channels!Redox biology · 2021Review
- Inhibitory Effect of Bovine Adipose-Derived Mesenchymal Stem Cells on Lipopolysaccharide Induced Inflammation of Endometrial Epithelial Cells in Dairy Cows.Frontiers in veterinary science · 2021Article
- Curcumin mitigates the histopathological and molecular changes in sublingual glands in diabetic male rats.Journal of oral biology and craniofacial researchArticle
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functional insufficiency of salivary glands constitute the common oral complaints in both type 1 and type 2 diabetes mellitus. The treatment with stem cell could decrease diabetic-induced hyposalivation and improve the quality of life for patients.
objectiveThe current study designed to assess the biological outcome of systemic injection of stem cells on the parotid salivary gland in streptozotocin induced diabetic.
methodsTwenty-four albino rats received intra-peritoneal injection of 50 mg/kg streptozotocin for induction of diabetes and were divided into two groups (n = 12): Group I (control) were kept without any manipulation, Group II received intravenous injection of 1×106 of mesenchymal stem cells of bone marrow derived for two days. All rats were sacrificed at 1, 3 weeks, then the parotid glands were isolated, fixed and processed for Heamatoxylin and Eosin examination, immunohistochemical staining for aquaporin-5.
resultsgroup I groups showed intracellular cytoplasmic vacuoles and focal loss of salivary architecture, while group II showed maintenance of gland architecture. Immunohistochemical examination of aquaporin-5 showed significant difference between the two groups.
conclusionbone marrow derived stem cell treatment considers as an improved methods in prevention and treatment of diabeticinduced hyposalivation.
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