ArticleGastroenterology and hepatology from bed to bench2019
Mixture cure model for estimating short-term and long-term colorectal cancer survival.
Article in Gastroenterology and hepatology from bed to bench, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Estimating Short-Term and Long-Term Survival for Patients With Kidney Failure Using a Mixture Survival Model.Kidney medicine · 2026Article
- Using mixture cure models to address algorithmic bias in diagnostic timing: autism as a test case.JAMIA open · 2025Article
- A new cure model accounting for longitudinal data and flexible patterns of hazard ratios over time.Statistical methods in medical research · 2025Article
- INDIVIDUAL DYNAMIC PREDICTION FOR CURE AND SURVIVAL BASED ON LONGITUDINAL BIOMARKERS.The annals of applied statistics · 2024Article
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Authors and funding
5 authors.
Funding
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Abstract
aimWe used mixture cure mode to separately investigate the risk factors for long-term and short-term survival of colorectal cancer patients.
backgroundColorectal cancer (CRC) is the second most common cancer worldwide. In cancer studies, patients' survival is the most important indicator of patients' status. Classical methods in analyzing the survival data usually apply Cox proportional hazard regression.
methodsThe study was performed on 1121 patients diagnosed with colorectal cancer. Mixture cure model with Weibull distribution and logit link function was fitted to data.
resultsOdds of long-term survival for rectum cancer patients were lower than for colon cancer patients (OR=0.29(0.09, 0.9)). Also, patients with the advanced stage of the disease had lower odds of long-term survival compared to early-stage patients (OR=0.24(0.06, 0.86)).In the short-term, the hazard of death for people with normal BMI was lower than the underweight group (HR=0.4(0.21, 0.76)). The short-term hazard of death for rectum cancer was about half of the short-term hazard for colon cancer (HR=0.49(0.29, 0.81)). Further, people with moderately (HR=2.11(1.26, 3.55)) and poorly (HR=4.04(2.03, 8.03)) differentiated tumor grade had a higher short-term hazard of death compared to people with well-differentiated grade.
conclusionPredictive variables of colorectal cancer survival showed different effects in short- and long -terms. Site topography was a prognosis for both long-term and short-term survival; BMI and tumor grade were short-term predictors of survival while stage was a long-term predictor of survival.
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