Evidence map›Paper›PMID 32099589›Full record

ArticleThe World Allergy Organization journal2020

Novel salivary gland allergens from tropical mosquito species and IgE reactivity in allergic patients.

Anunya Opasawatchai, Watchareewan Yolwong, Walairat Thuncharoen, Nanthicha Inrueangsri, Sulak Itsaradisaikul, Cherapat Sasisakulporn, Wanlapa Jotikasthira, Oranart Matangkasombut, Onrapak Reamtong, Wiparat Manuyakorn and 2 more

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. eLife · 2021
    Pooled it
  2. Review
  3. Article
  4. Article
  5. IgE response to Aed al 13 and Aed al 14 recombinant allergens fromThe World Allergy Organization journal · 2023
    Article
  6. Bioengineered · 2022
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anunya OpasawatchaiDepartment of Microbiology, Faculty of Science, Mahidol University, Thailand.
Watchareewan YolwongToxicology Graduate Program, Faculty of Science, Mahidol University, Thailand.
Walairat ThuncharoenDepartment of Microbiology, Faculty of Science, Mahidol University, Thailand.
Nanthicha InrueangsriDepartment of Microbiology, Faculty of Science, Mahidol University, Thailand.
Sulak ItsaradisaikulDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
Cherapat SasisakulpornDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
Wanlapa JotikasthiraDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
Oranart MatangkasombutDepartment of Microbiology and Research Unit on Oral Microbiology and Immunology, Faculty of Dentistry, Chulalongkorn University, Thailand.
Onrapak ReamtongDepartment of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Thailand.
Wiparat ManuyakornDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
Wisuwat SongnuanDepartment of Plant Science, Faculty of Science, Mahidol University, Thailand.
Ponpan MatangkasombutDepartment of Microbiology, Faculty of Science, Mahidol University, Thailand.
Mahidol University · THChulalongkorn University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMosquito allergy is common in tropical countries but remains under-diagnosed. This may be due to the lack of knowledge and diagnostic tools for tropical mosquito allergens.

objectiveWe aimed to characterize allergens from tropical mosquito species and investigate IgE reactivity in mosquito-allergic patients to the salivary gland proteins from these mosquitoes.

methodsSalivary gland extract (SGE) from 4 mosquito species, highly distributed in the tropics, including

resultsMosquito-allergic subjects have detectable serum IgE to SGE derived from local mosquito species, while the IgE levels to CONCLUSIONS & CLINICAL RELEVANCE: Five novel allergens from 3 tropical mosquito species were characterized. The majority of mosquito-allergic subjects who live in the tropics have IgE reactivity to these allergens. Our study paves the way for the development of diagnostic tests, component-resolved diagnostics, and future immunotherapy for mosquito allergy in tropical countries.

Indexed as

AllergensIgEInsect allergyMosquitoTropical species

Identifiers

PMID32099589
PMCPMC7031643
OpenAlexW3005898471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.