Evidence map›Paper›PMID 32099412›Full record

ArticleJournal of asthma and allergy2020

Prevalence and Predictors of Uncontrolled Asthma in Children Referred for Asthma and Other Atopic Diseases.

H M Kansen, T M Le, Cspm Uiterwaal, B E van Ewijk, Waf Balemans, Dmw Gorissen, E de Vries, M F van Velzen, Ghpr Slabbers, Y Meijer and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of asthma and allergy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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  11. Recent progress in the genetic and epigenetic underpinnings of atopy.The Journal of allergy and clinical immunology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

H M KansenDepartment of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0003-1446-7704
T M LeDepartment of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
Cspm UiterwaalJulius Center for Health Science and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
B E van EwijkDepartment of Pediatrics, Tergooi Hospital, Blaricum, The Netherlands.
Waf BalemansDepartment of Pediatrics, St. Antonius Hospital, Nieuwegein, The Netherlands.
Dmw GorissenDepartment of Pediatrics, Deventer Hospital, Deventer, The Netherlands.
E de VriesDepartment of Pediatrics, Jeroen Bosch Academie (Research), Jeroen Bosch Hospital, 'S Hertogenbosch, The Netherlands.ORCID 0000-0003-4311-3550
M F van VelzenDepartment of Pediatrics, Meander Medical Center, Amersfoort, The Netherlands.ORCID 0000-0003-2577-9308
Ghpr SlabbersDepartment of Pediatrics, Bernhoven Hospital, Uden, The Netherlands.
Y MeijerDepartment of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
A C KnulstDepartment of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
C K van der EntDepartment of Pediatric Pulmonology and Allergology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
F C van ErpDepartment of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.
University Medical Center Utrecht · NLDeventer Ziekenhuis · NLJeroen Bosch Ziekenhuis · NLMeander Medisch Centrum · NLSt. Antonius Ziekenhuis · NLTergooi · NLUtrecht University · NLZiekenhuis Bernhoven · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUncontrolled asthma in children is still highly prevalent despite the availability of effective asthma treatment. We investigated 1) the prevalence of uncontrolled asthma among children referred for asthma and referred for atopic diseases other than asthma (ie food allergy, allergic rhinitis or atopic dermatitis) to secondary care; and 2) the predictors associated with uncontrolled asthma.

methodsAll children (4 to 18 years) referred for asthma or atopic diseases other than asthma to 8 secondary care centers in The Netherlands were invited to an electronic portal (EP). The EP is a web-based application with several validated questionnaires including the ISAAC questionnaires and the Asthma Control Test (ACT). Children were eligible for inclusion in this study when their parents reported in the EP that their child had asthma diagnosed by a physician. The ACT was used to assess asthma control. Multiple predictors of asthma control (patient, asthma and atopic characteristics) were evaluated by univariable and multivariable logistic regression analyses.

resultsWe included 408 children: 259 children (63%) with asthma referred for asthma and 149 children (37%) with asthma referred for atopic diseases other than asthma. Thirty-nine percent of all children had uncontrolled asthma: 47% of the children referred for asthma and 26% of the children referred for atopic diseases other than asthma. Predictors associated with uncontrolled asthma were a family history of asthma (odds ratio [OR] 2.08; 95% confidence interval [95% CI] 1.34 to 3.24), and recurrent upper and lower respiratory tract infections in the past year (OR 2.40; 95% CI 1.52 to 3.81 and OR 2.00; 95% CI 1.25 to 3.23, respectively).

conclusionUncontrolled asthma is highly prevalent in children with asthma referred to secondary care, even if children are primarily referred for atopic diseases other than asthma. Thus, attention should be paid to asthma control in this population.

Indexed as

asthmaasthma controlatopic diseasesprognosisrespiratory tract infections

Identifiers

PMID32099412
PMCPMC6999583
OpenAlexW3003789165

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.