Evidence map›Paper›PMID 32099364›Full record

ArticleInternational journal of nanomedicine2020

Oral Deliverable Mucoadhesive Chitosan-

Sankar Renu, Ashley D Markazi, Santosh Dhakal, Yashavanth S Lakshmanappa, Revathi Shanmugasundaram, Ramesh K Selvaraj, Gourapura J Renukaradhya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Orally delivered chitosan-basedFrontiers in immunology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Pre-Harvest Non-TyphoidalAnimals : an open access journal from MDPI · 2024
    Review
  12. Article
  13. Microorganisms · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Current Progress and Challenges in the Study of Adjuvants for Oral Vaccines.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sankar RenuFood Animal Health Research Program, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-4197-9684
Ashley D MarkaziDepartment of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Columbus, OH, USA.
Santosh DhakalFood Animal Health Research Program, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-4494-8608
Yashavanth S LakshmanappaFood Animal Health Research Program, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Revathi ShanmugasundaramDepartment of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Columbus, OH, USA.
Ramesh K SelvarajDepartment of Poultry Science, University of Georgia, Athens, GA 30602, USA.
Gourapura J RenukaradhyaFood Animal Health Research Program, Ohio Agricultural Research and Development Center, Wooster, OH 44691, USA and Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0003-2861-180X
The Ohio State University · USUniversity of Georgia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSalmonellosis in poultry is a serious economic burden. A major concern is the public health hazard caused by consumption of MATERIALS AND

methodsA

resultsWe demonstrated targeting of surface F-protein coated chitosan NPs to immune cells when delivered orally to layer chickens, the particles were localized in ileal Peyer's patches. The OMPs-F-CS NPs vaccinated layer chickens had significantly higher OMPs-specific mucosal IgA production and lymphocyte proliferation response. The candidate vaccine increased the expression of toll-like receptor (TLR)-2, TLR-4, IFN-γ, TGF-ß and IL-4 mRNA expression in chicken cecal tonsils.

conclusionOur study demonstrated that the chitosan-based oral

Indexed as

ChickensAdministration, OralAnimalsChitosanFemaleImmunity, CellularInterleukin-4Intestinal MucosaNanoparticlesPorinsSalmonella enteritidisSalmonella Infections, AnimalSalmonella VaccinesToll-Like ReceptorsTransforming Growth Factor betaVaccines, SubunitChitosanInterleukin-4OmpF proteinPorinsSalmonella VaccinesToll-Like ReceptorsTransforming Growth Factor betaVaccines, Subunitchickenschitosan nanoparticlemucosal immune responseoral deliverySalmonella antigens

Identifiers

PMID32099364
PMCPMC7006855
OpenAlexW3004068230

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.