Evidence map›Paper›PMID 32099335›Full record

ArticlePatient preference and adherence2019

Side Effects, Self-Management Activities, and Adherence to Oral Anticancer Agents.

Yun Jiang, Karen E Wickersham, Xingyu Zhang, Debra L Barton, Karen B Farris, John C Krauss, Marcelline R Harris

Abstract read
In one paragraph

Article in Patient preference and adherence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Patient symptoms, confidence, and adherence during the first 8 weeks of targeted oral anticancer agent treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  7. Article
  8. Oncology patients' willingness to report their medication safety concerns from home: a qualitative study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Enhancing Safety via Medication Self-Management and Timely Reporting.Studies in health technology and informatics · 2021
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yun JiangUniversity of Michigan School of Nursing, Ann Arbor, MI, USA.ORCID 0000-0001-6737-5016
Karen E WickershamUniversity of South Carolina College of Nursing, Columbia, SC, USA.ORCID 0000-0003-0214-4596
Xingyu ZhangUniversity of Michigan School of Nursing, Ann Arbor, MI, USA.
Debra L BartonUniversity of Michigan School of Nursing, Ann Arbor, MI, USA.ORCID 0000-0001-6624-3476
Karen B FarrisUniversity of Michigan College of Pharmacy, Ann Arbor, MI, USA.ORCID 0000-0002-5636-3009
John C KraussUniversity of Michigan Medical School, Michigan Medicine, Ann Arbor, MI, USA.
Marcelline R HarrisUniversity of Michigan School of Nursing, Ann Arbor, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere are growing concerns about patients' adherence to oral anticancer agents (OAAs), and the need for patients to engage in self-management of OAA-related side effects. We assessed associations among adherence, severity of side effects, and effectiveness of self-management of side effects in patients taking capecitabine.

methodsAdherence to capecitabine at 6 weeks was measured by the Medication Event Monitoring System among 50 patients with gastrointestinal cancers. Severity of side effects related to capecitabine and effectiveness of self-management of side effects were captured using the Modified Self-Care Diary at the time of enrollment and weekly for 6 weeks. Spearman's correlation, Mann-Whitney

resultsOverall mean adherence rate was 85.4±14.1%. Adherence rate was not significantly correlated to the mean severity of total side effects at any time point and was correlated with the mean effectiveness of self-management of total side effects only at week 2 (

conclusionThis pilot study suggests ongoing examination of both severity and effectiveness of self-management of side effects in future studies of adherence to OAAs is merited. There is a need for future studies with larger sample sizes that explore the complex relationships among adherence, severity of side effects, and effectiveness of self-management of side effects in OAA therapy.

Indexed as

adherenceoral anticancer agentsself-managementside effects

Identifiers

PMID32099335
PMCPMC6997414

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.