Evidence map›Paper›PMID 32099035›Full record

ArticleLeukemia2020

Inhibition of LSD1 in MDS progenitors restores differentiation of CD141

Pragya Srivastava, Stephanie L Tzetzo, Eduardo Cortes Gomez, Kevin H Eng, Sheila N Jani Sait, Joseph B Kuechle, Prashant K Singh, Kitty De Jong, Kyle R Wiatrowski, Jennifer Peresie and 6 more

Open access · greenAbstract read
In one paragraph

Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Pragya SrivastavaDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Stephanie L Tzetzo *Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.ORCID http://orcid.org/0000-0002-4088-6331
Eduardo Cortes Gomez *Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Kevin H Eng *Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Sheila N Jani SaitDepartment of Pathology and Laboratory Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Joseph B KuechleDepartment of Orthopaedics, University at Buffalo, Buffalo, NY, USA.
Prashant K SinghCenter for Personalized Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Kitty De JongFlow and Image Cytometry Shared Resource, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Kyle R WiatrowskiDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Jennifer PeresieDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Ava DimitroffDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Miranda L LynchDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Jianmin WangDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Scott I AbramsDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.ORCID http://orcid.org/0000-0002-8742-4708
Elizabeth A GriffithsDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. Elizabeth.Griffiths@RoswellPark.org.
Michael J NemethDepartment of Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA. Michael.Nemeth@RoswellPark.org.
Roswell Park Comprehensive Cancer Center · USUniversity at Buffalo, State University of New York · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
Immuno-Oncology Translation Network: Data Management and Resource-Sharing Center at RPCIU24CA232979 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HUTSON, ALAN DAVID, LIU, SONG · 2018 to 2024
$8.9M
CD28-mediated Regulation of Multiple Myeloma Cell Proliferation and SurvivalR01CA121044 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI LEE, KELVIN P. · 2007 to 2023
$4.8M
MULTIDISCIPLINARY APPROACHES TUMOR IMMUNOLOGYT32CA085183 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Scott I. Abrams · 2001 to 2026
$3.1M
Mechanisms Underlying Functional Programs of Tumor-Associated MacrophagesR01CA172105 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI ABRAMS, SCOTT I. · 2015 to 2019
$2.0M
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA121044NCI NIH HHS R01 CA172105NCI NIH HHS T32 CA085183NCI NIH HHS U24 CA232979
6 · The paper itself

Abstract

The use of immunotherapy to treat patients with myelodysplastic syndromes (MDS) shows promise but is limited by our incomplete understanding of the immunologic milieu. In solid tumors, CD141

Indexed as

Cell DifferentiationAnimalsAntigens, SurfaceDendritic CellsEpigenesis, GeneticFemaleHistone DemethylasesHumansInterferon Regulatory Factor-8Interferon Regulatory FactorsMiceMice, KnockoutMyelodysplastic SyndromesNeoplastic Stem CellsThrombomodulinAntigens, SurfaceHistone DemethylasesInterferon Regulatory Factor-8Interferon Regulatory FactorsKDM1A protein, humanTHBD protein, humanThrombomodulin

Identifiers

PMID32099035
PMCPMC7483249
OpenAlexW3008930142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.