ArticleScientific reports2020
γ-Aminobutyric acid confers cadmium tolerance in maize plants by concerted regulation of polyamine metabolism and antioxidant defense systems.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 130 citations in OpenAlex.
- γ-Aminobutyric Acid Alleviates Cadmium Toxicity and Is Associated with Increased Ascorbate and Glutathione Levels inInternational journal of molecular sciences · 2026Article
- Decoding the multifunctional role of γ-aminobutyric acid in plant adaptation to drought stress.Planta · 2026Review
- Trichoderma genome and multiomics insight into promoting yield and reducing grain cadmium in barley and wheat.Journal of integrative plant biology · 2026Article
- GABA-mediated regulation of lipid metabolism: a conserved relation with diverse physiological significances.Frontiers in physiology · 2026Review
- Decoding polyamine-ethylene dynamics: synergies at synthesis and signalling levels during osmotic stress and ripening.Frontiers in plant science · 2026Review
- Does Folcisteine (NATCA) Play a Role in Facilitating Seed Germination, Root Development, and Elevating Root AsA-GSH Cycle Efficiency Under Combined Copper-Cadmium Stress in Maize?International journal of molecular sciences · 2025Article
- Mitigating effect of γ-aminobutyric acid and gibberellic acid on tomato plant cultivated in Pb-polluted soil.Scientific reports · 2025Article
- Physiological and transcriptomic evidence revealed the role of exogenous GABA in enhancing salt tolerance in strawberry seedlings.BMC genomics · 2025Article
- Relationship between the GABA Pathway and Signaling of Other Regulatory Molecules.International journal of molecular sciences · 2024Review
- β-Aminobutyric acid promotes stress tolerance, physiological adjustments, as well as broad epigenetic changes at DNA and RNA nucleobases in field elms (Ulmus minor).BMC plant biology · 2024Article
- Exogenous GABA Enhances Copper Stress Resilience in Rice Plants via Antioxidant Defense Mechanisms, Gene Regulation, Mineral Uptake, and Copper Homeostasis.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Cadmium and copper-induced metabolic and proteomic changes in the root tip during early maize growth.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Gamma-aminobutyric acid treatment promotes resistance againstFrontiers in plant science · 2024Article
- Investigation into the Relationship between Spermidine Degradation and Phenolic Compounds Biosynthesis in Barley Seedlings under Ultraviolet B Stress.Plants (Basel, Switzerland) · 2023Article
- Why did glutamate, GABA, and melatonin become intercellular signalling molecules in plants?eLife · 2023Review
- Response to Cadmium Toxicity: Orchestration of Polyamines and microRNAs in Maize Plant.Plants (Basel, Switzerland) · 2023Article
- Gamma-Aminobutyric Acid Enhances Cadmium Phytoextraction byPlants (Basel, Switzerland) · 2023Article
- Physiology of gamma-aminobutyric acid treated Capsicum annuum L. (Sweet pepper) under induced drought stress.PloS one · 2023Article
- Molecular Mechanisms Underlying Flax (Plants (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gamma-Aminobutyric acid (GABA) accumulates in plants following exposure to heavy metals. To investigate the role of GABA in cadmium (Cd) tolerance and elucidate the underlying mechanisms, GABA (0, 25 and 50 µM) was applied to Cd-treated maize plants. Vegetative growth parameters were improved in both Cd-treated and control plants due to GABA application. Cd uptake and translocation were considerably inhibited by GABA. Antioxidant enzyme activity was enhanced in plants subjected to Cd. Concurrently GABA caused further increases in catalase and superoxide dismutase activities, which led to a significant reduction in hydrogen peroxide, superoxide anion and malondealdehyde contents under stress conditions. Polyamine biosynthesis-responsive genes, namely ornithine decarboxylase and spermidine synthase, were induced by GABA in plants grown under Cd shock. GABA suppressed polyamine oxidase, a gene related to polyamine catabolism, when plants were exposed to Cd. Consequently, different forms of polyamines were elevated in Cd-exposed plants following GABA application. The maximum quantum efficiency of photosystem II (F
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