Evidence map›Paper›PMID 32098870›Full record

ArticleThe Journal of biological chemistry2020

The roles of polymerases ν and θ in replicative bypass of

Hua Du, Pengcheng Wang, Jun Wu, Xiaomei He, Yinsheng Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Multifaceted Nature of DNA Polymerase θ.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
  5. Beyond the Lesion: Back to High Fidelity DNA Synthesis.Frontiers in molecular biosciences · 2021
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hua DuDepartment of Chemistry, University of California, Riverside, California 92521-0403.
Pengcheng WangDepartment of Chemistry, University of California, Riverside, California 92521-0403.
Jun WuDepartment of Chemistry, University of California, Riverside, California 92521-0403.
Xiaomei HeDepartment of Chemistry, University of California, Riverside, California 92521-0403.
Yinsheng WangDepartment of Chemistry, University of California, Riverside, California 92521-0403 Yinsheng.Wang@ucr.edu.ORCID 0000-0001-5565-283X
University of California, Riverside · US

Funding

A Targeted DNA Adductomics Approach for Analyzing > 100 DNA AdductsR01ES029749 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI WANG, YINSHENG · 2018 to 2022
$1.7M
NIEHS NIH HHS R01 ES029749
6 · The paper itself

Abstract

Exogenous and endogenous chemicals can react with DNA to produce DNA lesions that may block DNA replication. Not much is known about the roles of polymerase (Pol) ν and Pol θ in translesion synthesis (TLS) in cells. Here we examined the functions of these two polymerases in bypassing major-groove

Indexed as

AlkylationChromatography, High Pressure LiquidDeoxyguanosineDNA-Directed DNA PolymeraseDNA Polymerase thetaDNA RepairHEK293 CellsHumansMutagenesisTandem Mass Spectrometry8-nitro-2'-deoxyguanosineDeoxyguanosineDNA-Directed DNA PolymeraseDNA Polymerase thetaPOLN protein, humanDNA alkylationDNA damageDNA polymeraseDNA replicationMSmutagenesismutagenesis mechanismpolymerase θpolymerase ν

Identifiers

PMID32098870
PMCPMC7135994
OpenAlexW3008363679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.