Evidence map›Paper›PMID 32098818›Full record

ArticlemBio2020

An Endoplasmic Reticulum CREC Family Protein Regulates the Egress Proteolytic Cascade in Malaria Parasites.

Manuel A Fierro, Beejan Asady, Carrie F Brooks, David W Cobb, Alejandra Villegas, Silvia N J Moreno, Vasant Muralidharan

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Knock-sideways by inducible ER retrieval enables a unique approach for studyingProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. GeneTargeter: AutomatedThe CRISPR journal · 2022
    Article
  14. Article
  15. Article
  16. Review
  17. Malaria parasite egress at a glance.Journal of cell science · 2021
    Review
  18. Article
  19. Calcium in the Backstage of Malaria Parasite Biology.Frontiers in cellular and infection microbiology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Manuel A FierroCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Beejan AsadyCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Carrie F BrooksCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
David W CobbCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Alejandra VillegasCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.
Vasant MuralidharanCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA vasant@uga.edu.ORCID 0000-0001-6367-6284
University of Georgia · US

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
The Toxoplasma apicoplast and calcium signalingR01AI128356 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2017 to 2021
$2.0M
Regulation of calcium signaling in the human malaria parasiteR21AI133322 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N, MURALIDHARAN, VASANT · 2018 to 2019
$414k
NIAID NIH HHS R01 AI128356NIAID NIH HHS R21 AI133322NIAID NIH HHS T32 AI060546
6 · The paper itself

Abstract

The endoplasmic reticulum (ER) is thought to play an essential role during egress of malaria parasites because the ER is assumed to be required for biogenesis and secretion of egress-related organelles. However, no proteins localized to the parasite ER have been shown to play a role in egress of malaria parasites. In this study, we generated conditional mutants of the

Indexed as

ProteolysisCalcium-Binding ProteinsEndoplasmic ReticulumGene Knockout TechniquesHumansMalariaMalaria, FalciparumPeptide HydrolasesPlasmodium falciparumProtozoan ProteinsVacuolesCalcium-Binding ProteinsPeptide HydrolasesProtozoan Proteinscalcium-binding proteinegressendoplasmic reticulummalariaPlasmodium

Identifiers

PMID32098818
PMCPMC7042697
OpenAlexW3007063328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.