Evidence map›Paper›PMID 32098806›Full record

ArticleHeart (British Cardiac Society)2020

Age at period cessation and trajectories of cardiovascular risk factors across mid and later life.

Linda Marie O'Keeffe, Diana Kuh, Abigail Fraser, Laura D Howe, Debbie Lawlor, Rebecca Hardy

Abstract read
In one paragraph

Article in Heart (British Cardiac Society), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Sex-based differences in short- and longer-term diet-induced metabolic heart disease.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Cardiometabolic Risk Trajectory Among Older Americans: Findings From the Health and Retirement Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Association of Body Shape Index (ABSI) with Hand Grip Strength.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Linda Marie O'KeeffeMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK linda.okeeffe@bristol.ac.uk.ORCID 0000-0002-0003-0774
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, London, UK.ORCID 0000-0001-7386-2857
Abigail FraserMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-7741-9470
Laura D HoweMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Debbie LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-6793-2262
Rebecca HardyMRC Unit for Lifelong Health and Ageing at UCL, London, UK.

Funding

Medical Research Council G1001357Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12019/1Medical Research Council MC_UU_12019/2Medical Research Council MC_UU_12019/4Medical Research Council MR/M009351/1Medical Research Council MR/M014509/1Medical Research Council MR/M020894/1
6 · The paper itself

Abstract

objectiveTo examine the association between age at period cessation and trajectories of anthropometry, blood pressure, lipids and glycated haemoglobin (HbA1c) from midlife to age 69 years.

methodsWe used data from the UK Medical Research Council National Survey of Health and Development to examine the association between age at period cessation and trajectories of systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI) and waist circumference (WC) from 36 to 69 years and trajectories of triglyceride, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and HbA1c from 53 to 69 years.

resultsWe found no evidence that age at period cessation was associated with trajectories of log triglyceride, LDL-C and HDL-C from 53 to 69 years and trajectories of SBP or DBP from 36 to 69 years, regardless of whether period cessation occurred naturally or due to hysterectomy. While we found some evidence of associations of age at period cessation with log BMI, log WC and log HbA1c, patterns were not consistent and differences were small at age 69 years, with confidence intervals that spanned the null value.

conclusionHow and when women experience period cessation is unlikely to adversely affect conventional cardiovascular risk factors across mid and later life. Women and clinicians concerned about the impact of type and timing of period cessation on conventional cardiovascular intermediates from midlife should be reassured that the impact over the long term is small.

Indexed as

MenopauseAgedAge FactorsBlood PressureBody Mass IndexCardiovascular DiseasesFemaleGlycated HemoglobinHumansLipidsMiddle AgedProspective StudiesRisk FactorsWaist CircumferenceGlycated HemoglobinLipidscardiac risk factors and preventionepidemiology

Identifiers

PMID32098806
PMCPMC7079196

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.