ArticleGenome research2020
Human auditory ossicles as an alternative optimal source of ancient DNA.
Article in Genome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
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- µCT scanning effects on aDNA and a multi-step workflow for archaeological petrous portions.PloS one · 2026Article
- Ancient DNA reveals the population interactions and a Neolithic patrilineal community in Northern Yangtze Region.Nature communications · 2025Article
- A High-Throughput Ancient DNA Extraction Method for Large-Scale Sample Screening.Molecular ecology resources · 2025Article
- Patellae as a source of DNA in forensic and archaeological analysis.International journal of legal medicine · 2025Article
- The genetic origin of the Indo-Europeans.Nature · 2025Article
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- Evaluation of a New DNA Extraction Method on Challenging Bone Samples Recovered from a WWII Mass Grave.Genes · 2024Article
- The Genetic Origin of the Indo-Europeans.bioRxiv : the preprint server for biology · 2024Article
- A fresh perspective on infrared spectroscopy as a prescreening method for molecular and stable isotopes analyses on ancient human bones.Scientific reports · 2024Article
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- Genetic sexing of subadult skeletal remains.Scientific reports · 2023Article
- Review: Computational analysis of human skeletal remains in ancient DNA and forensic genetics.iScience · 2023Review
- Eye and hair color prediction of an early medieval adult and subadult skeleton using massive parallel sequencing technology.International journal of legal medicine · 2023Article
- Improving kinship probability in analysis of ancient skeletons using identity SNPs and MPS technology.International journal of legal medicine · 2023Article
Corrections and comments
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Authors and funding
39 authors at 20 institutions in 14 countries.
Funding
Abstract
DNA recovery from ancient human remains has revolutionized our ability to reconstruct the genetic landscape of the past. Ancient DNA research has benefited from the identification of skeletal elements, such as the cochlear part of the osseous inner ear, that provides optimal contexts for DNA preservation; however, the rich genetic information obtained from the cochlea must be counterbalanced against the loss of morphological information caused by its sampling. Motivated by similarities in developmental processes and histological properties between the cochlea and auditory ossicles, we evaluate the ossicles as an alternative source of ancient DNA. We show that ossicles perform comparably to the cochlea in terms of DNA recovery, finding no substantial reduction in data quantity and minimal differences in data quality across preservation conditions. Ossicles can be sampled from intact skulls or disarticulated petrous bones without damage to surrounding bone, and we argue that they should be used when available to reduce damage to human remains. Our results identify another optimal skeletal element for ancient DNA analysis and add to a growing toolkit of sampling methods that help to better preserve skeletal remains for future research while maximizing the likelihood that ancient DNA analysis will produce useable results.
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