Evidence map›Paper›PMID 32098763›Full record

ArticleDevelopment (Cambridge, England)2020

Membrane expression of the estrogen receptor ERα is required for intercellular communications in the mammary epithelium.

Laurine Gagniac, Mariam Rusidzé, Frederic Boudou, Stephanie Cagnet, Marine Adlanmerini, Pauline Jeannot, Nicolas Gaide, Frank Giton, Arnaud Besson, Ariane Weyl and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Estetrol and Mammary Gland: Friends or Foes?Journal of mammary gland biology and neoplasia · 2021
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Laurine GagniacINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.
Mariam RusidzéINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.
Frederic BoudouINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.
Stephanie CagnetSwiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Marine AdlanmeriniINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.ORCID 0000-0001-5230-2797
Pauline JeannotLBCMCP, Centre de Biologie Intégrative, Université de Toulouse, CNRS, Toulouse 31062, France.
Nicolas GaideLabHPEC Laboratoire d'HistoPathologie Expérimentale et Comparée STROMALab, Université de Toulouse, CNRS ERL5311, EFS, ENVT, Inserm U1031, UPS, Toulouse 31300, France.
Frank GitonAPHP H.Mondor- IMRB - INSERM U955, Créteil 94010, France.
Arnaud BessonLBCMCP, Centre de Biologie Intégrative, Université de Toulouse, CNRS, Toulouse 31062, France.
Ariane WeylINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.
Pierre GourdyINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.
Isabelle Raymond-LetronLabHPEC Laboratoire d'HistoPathologie Expérimentale et Comparée STROMALab, Université de Toulouse, CNRS ERL5311, EFS, ENVT, Inserm U1031, UPS, Toulouse 31300, France.
Jean-Francois ArnalINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France.
Cathrin BriskenSwiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
Francoise LenfantINSERM U1048, I2MC, Université de Toulouse, Toulouse 31432, France francoise.lenfant@inserm.fr.ORCID 0000-0003-0024-7241
Inserm · FRCentre National de la Recherche Scientifique · FRÉcole Polytechnique Fédérale de Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

17β-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ERα. ERα acts as a transcription factor but also elicits rapid signaling through a fraction of ERα expressed at the membrane. Here, we have used the C451A-ERα mouse model mutated for the palmitoylation site to understand how ERα membrane signaling affects mammary gland development. Although the overall structure of physiological mammary gland development is slightly affected, both epithelial fragments and basal cells isolated from C451A-ERα mammary glands failed to grow when engrafted into cleared wild-type fat pads, even in pregnant hosts. Similarly, basal cells purified from hormone-stimulated ovariectomized C451A-ERα mice did not produce normal outgrowths.

Indexed as

AnimalsEpithelial CellsEpitheliumEstradiolEstrogen Receptor alphaFemaleGene Expression ProfilingGene Expression RegulationLipoylationMammary Glands, AnimalMiceMice, Inbred C57BLMice, TransgenicParacrine CommunicationSignal TransductionEstradiolEstrogen Receptor alphaECMEstrogen receptor alphaMammary glandMembrane initiated signalingParacrine signalsStem cells

Identifiers

PMID32098763
PMCPMC7075076
OpenAlexW3008101360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.