Evidence map›Paper›PMID 32098762›Full record

ArticleeNeuro

Propagating Activity in Neocortex, Mediated by Gap Junctions and Modulated by Extracellular Potassium.

Christoforos A Papasavvas, R Ryley Parrish, Andrew J Trevelyan

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christoforos A PapasavvasInstitute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.ORCID 0000-0001-9122-2925
R Ryley ParrishInstitute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom.ORCID 0000-0001-6798-6140
Andrew J TrevelyanInstitute of Neuroscience, Newcastle University Medical School, Newcastle upon Tyne NE2 4HH, United Kingdom andrew.trevelyan@ncl.ac.uk.ORCID 0000-0001-9307-4241
Newcastle University · GB

Funding

Medical Research Council MR/J013250/1Medical Research Council MR/R005427/1Wellcome Trust 099755/Z/12/Z
6 · The paper itself

Abstract

Parvalbumin-expressing interneurons in cortical networks are coupled by gap junctions, forming a syncytium that supports propagating epileptiform discharges, induced by 4-aminopyridine. It remains unclear, however, whether these propagating events occur under more natural states, without pharmacological blockade. In particular, we investigated whether propagation also happens when extracellular K

Indexed as

NeocortexPharmaceutical PreparationsGap JunctionsInterneuronsPotassiumPharmaceutical PreparationsPotassiumelectrotonicexcitabilitygap junctionparvalbuminpotassiumseizure

Identifiers

PMID32098762
PMCPMC7096537
OpenAlexW3008784991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.