ArticleTissue engineering. Part A2021
Influence of Geometry and Architecture on the
Article in Tissue engineering. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluation of the Biological Response to Coating 3D-Printed PLA Scaffolds with Coaxial Gelatin-Based Electrospun Fibers.Biomimetics (Basel, Switzerland) · 2026Article
- Transforming spinal surgery with innovations in biologics and additive manufacturing.Materials today. Bio · 2025Review
- The Use of Platelet-Rich Fibrin-Coated Three-Dimensionally (3D) Printed Scaffolds in Salvage of Complex Hindfoot Cases.Biomimetics (Basel, Switzerland) · 2025Article
- Comparison of Bone Graft Preparations to Treat a Critical Bone Defect on a Rodent Animal Model.Revista brasileira de ortopedia · 2024Article
- Advantages of Using 3D Spheroid Culture Systems in Toxicological and Pharmacological Assessment for Osteogenesis Research.International journal of molecular sciences · 2024Review
- Recent Advances in Bioengineering Bone Revascularization Based on Composite Materials Comprising Hydroxyapatite.International journal of molecular sciences · 2023Review
- Customized Additive Manufacturing in Bone Scaffolds-The Gateway to Precise Bone Defect Treatment.Research (Washington, D.C.) · 2023Review
- 3D-Printing for Critical Sized Bone Defects: Current Concepts and Future Directions.Bioengineering (Basel, Switzerland) · 2022Review
- Novel Approaches Guiding the Future of Spinal Biologics for Bone Regeneration.Current reviews in musculoskeletal medicine · 2022Review
- Osteoinductivity and biomechanical assessment of a 3D printed demineralized bone matrix-ceramic composite in a rat spine fusion model.Acta biomaterialia · 2021Article
- Synthetic Bone Graft Materials in Spine Fusion: Current Evidence and Future Trends.International journal of spine surgery · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
We previously developed a recombinant growth factor-free, three-dimensional (3D)-printed material comprising hydroxyapatite (HA) and demineralized bone matrix (DBM) for bone regeneration. This material has demonstrated the capacity to promote re-mineralization of the DBM particles within the scaffold struts and shows potential to promote successful spine fusion. Here, we investigate the role of geometry and architecture in osteointegration, vascularization, and facilitation of spine fusion in a preclinical model. Inks containing HA and DBM particles in a poly(lactide-co-glycolide) elastomer were 3D-printed into scaffolds with varying relative strut angles (90° vs. 45° advancing angle), macropore size (0 μm vs. 500 μm vs. 1000 μm), and strut alignment (aligned vs. offset). The following configurations were compared with scaffolds containing no macropores: 90°/500 μm/aligned, 45°/500 μm/aligned, 90°/1000 μm/aligned, 45°/1000 μm/aligned, 90°/1000 μm/offset, and 45°/1000 μm/offset. Eighty-four female Sprague-Dawley rats underwent spine fusion with bilateral placement of the various scaffold configurations (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.