Evidence map›Paper›PMID 32098412›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Functional Bioglass-Biopolymer Double Nanostructure for Natural Antimicrobial Drug Extracts Delivery.

Irina Negut, Laura Floroian, Carmen Ristoscu, Cristian N Mihailescu, Julia Claudia Mirza Rosca, Tatiana Tozar, Mihaela Badea, Valentina Grumezescu, Claudiu Hapenciuc, Ion N Mihailescu

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Pharmaceutics · 2022
    Article
  9. Review
  10. Biopolymers Hybrid Particles Used in Dentistry.Gels (Basel, Switzerland) · 2021
    Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Irina NegutNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.ORCID 0000-0003-4038-7548
Laura FloroianAutomation Dept, Faculty of Electrical Engineering and Computer Science, Transilvania University of Brasov, Brasov 500036, Romania.
Carmen RistoscuNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.ORCID 0000-0002-8433-9217
Cristian N MihailescuNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.
Julia Claudia Mirza RoscaUniversity of Las Palmas de Gran Canaria, Campus Universitario de Tafira, 35017 Las Palmas de Gran Canaria, Las Palmas, Spain.
Tatiana TozarNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.ORCID 0000-0002-5953-9241
Mihaela BadeaFundamental, Prophylactic and Clinical Specialties Department, Faculty of Medicine, Transilvania University of Brasov, Brasov 500036, Romania.ORCID 0000-0003-4824-2175
Valentina GrumezescuNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.
Claudiu HapenciucNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.
Ion N MihailescuNational Institute for Lasers, Plasma and Radiation Physics, Măgurele 077125, Romania.ORCID 0000-0001-9486-0420
National Institute for Laser Plasma and Radiation Physics · ROTransylvania University of Brașov · ROUniversidad de Las Palmas de Gran Canaria · ES

Funding

European Commission PRO-DD (POS-CCE, O.2.2.1., ID 123, SMIS 2637, ctr. No 11/2009)Ministerul Educației și Cercetării Științifice 16N/2019Transilvania University of Brasov, Romania 2017 FellowshipUnitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.1-PD-2016-1072Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P2-2.1-PED-2016-0621 no.146PED/2017
6 · The paper itself

Abstract

Aseptic loosening and periprosthetic infections are the main causes of implant failure. Strategies to mitigate this drawback are therefore mandatory to avoid primary and revision replacement surgeries. A functional bioapatite-biopolymer double nanostructure fabricated by matrix-assisted pulsed laser evaporation to prevent infection of orthopedic and dental implants could promote osseointegration and ensure controlled delivery of natural antimicrobial drugs. The synthesized nanostructure consists of two overlapping layers, the lower from a biocompatible polymer for anticorrosive protection, and the upper of bioactive glass incorporating antimicrobial plant extract, acting as a potential drug delivery system. Morphology, composition, adherence, ability for drug delivery and biological properties (cytotoxicity and antimicrobial effect) were studied. Structures proved compact and stable, conserving a remarkable drug delivery ability for more than 21 days, i.e., enough to ensure long-term microbes' eradication.

Indexed as

antimicrobial effectbioactive coatingsdrug releaseimplant protection

Identifiers

PMID32098412
PMCPMC7075305
OpenAlexW3007254574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.