Evidence map›Paper›PMID 32098402›Full record

ArticleCancers2020

The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer.

Carla Solé, Ibai Goicoechea, Alai Goñi, Maike Schramm, María Armesto, María Arestin, Lorea Manterola, Maitena Tellaetxe, Aitor Alberdi, Leonor Nogueira and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Prostate cancer in omics era.Cancer cell international · 2022
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. At the dawn of the transcriptomic medicine.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 4 countries.

Carla SoléMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.
Ibai GoicoecheaMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.ORCID 0000-0002-5329-2225
Alai GoñiRadiation Oncology, Onkologikoa Foundation, 20014 Gipuzkoa, Spain.
Maike SchrammMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.ORCID 0000-0002-8675-5732
María ArmestoMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.
María ArestinMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.
Lorea ManterolaMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.
Maitena TellaetxeMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.ORCID 0000-0003-1894-4547
Aitor AlberdiHernani Primary Care Health Center, OSI Donostialdea, 20120 Osakidetza, Spain.
Leonor NogueiraDepartment of Urology, Institut Universitaire du Cancer, 31100 Toulouse, France.
Mathieu RoumiguieDepartment of Urology, Institut Universitaire du Cancer, 31100 Toulouse, France.
Jose Ignacio LópezDepartment of Pathology, Cruces University Hospital, 48903 Barakaldo, Spain.ORCID 0000-0003-0842-5348
Juan Pablo Sanz JakaDepartment of Urology, Hospital Donostia, 20014 San Sebastián, Spain.
Ander UrruticoecheaOnkologikoa Foundation, 20014 Gipuzkoa, Spain.
Itziar VergaraUnidad de Investigación AP OSIs Gipuzkoa, Biodonostia Research Institute, 20014 San Sebastián, Spain.
Ana Loizaga-IriarteDepartment of Urology, Basurto University Hospital, 48013 Bilbao, Spain.
Miguel UndaDepartment of Urology, Basurto University Hospital, 48013 Bilbao, Spain.
Arkaitz CarracedoCIBERONC (Centro de Investigación Biomédica en Red de Cáncer), 28020 Madrid, Spain.
Bernard MalavaudDepartment of Urology, Institut Universitaire du Cancer, 31100 Toulouse, France.
Charles H LawrieMolecular Oncology group, Biodonostia Research Institute, 20014 San Sebastián, Spain.ORCID 0000-0002-8882-1131
Biogipuzkoa Health Research Institute · ESHospital de Basurto · ESIkerbasque · ESOnkologikoa · ESHeidelberg University · DEHôpital Purpan · FROsakidetza · ESUniversity of the Basque Country · ES

Funding

Instituto de Salud Carlos III PI12/00663, PIE13/00048, DTS14/00109, PI15/00275, PI18/01710
6 · The paper itself

Abstract

Prostate cancer (PCa) is the second most common cancer of men and is typically slow-growing and asymptomatic. The use of blood PSA as a screening method has greatly improved PCa diagnosis, but high levels of false positives has raised much interest in alternative biomarkers. We used next-generation sequencing (NGS) to elucidate the urinary transcriptome of whole urine collected from high-stage and low-stage PCa patients as well as from patients with the confounding diagnosis of benign hyperplasia (BPH). We identified and validated five differentially expressed protein-coding genes (

Indexed as

biomarkerliquid biopsymRNANGSprostate cancerPSAtranscriptome

Identifiers

PMID32098402
PMCPMC7072374
OpenAlexW3006749919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.