Evidence map›Paper›PMID 32098299›Full record

ArticleInternational journal of molecular sciences2020

Manipulating the In Vivo Behaviour of

Cinzia Imberti, Pierre Adumeau, Julia E Blower, Fahad Al Salemee, Julia Baguña Torres, Jason S Lewis, Brian M Zeglis, Samantha Y A Terry, Philip J Blower

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. TheEuropean journal of nuclear medicine and molecular imaging · 2026
    Observational
  2. Article
  3. Review
  4. In Vivo Detection ofInternational journal of biomedical imaging · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. [Bioconjugate chemistry · 2021
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Cinzia ImbertiSchool of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.ORCID 0000-0003-1187-7951
Pierre AdumeauDepartment of Chemistry, Hunter College, City University of New York, New York, NY 10021, USA.ORCID 0000-0002-7129-4507
Julia E BlowerSchool of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Fahad Al SalemeeSchool of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.ORCID 0000-0001-5701-3783
Julia Baguña TorresSchool of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.ORCID 0000-0001-8621-3549
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-7065-4534
Brian M ZeglisDepartment of Chemistry, Hunter College, City University of New York, New York, NY 10021, USA.ORCID 0000-0002-9091-744X
Samantha Y A TerrySchool of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.
Philip J BlowerSchool of Biomedical Engineering and Imaging Sciences, King's College London, Fourth Floor Lambeth Wing, St Thomas' Hospital, London SE1 7EH, UK.ORCID 0000-0001-6290-1590
St Thomas' Hospital · GBMemorial Sloan Kettering Cancer Center · USCity University of New York · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Pretargeted Clinical Imaging of CA19.9 in Pancreatic CancerU01CA221046 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ZEGLIS, BRIAN MATTHEW · 2018 to 2022
$3.5M
Cancer Research UK 16463Cancer Research UK Comprehensive Cancer Imaging CentreMedical Research Council MC_PC_16048NCI NIH HHS NIH NCI R35 CA232130NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA232130NCI NIH HHS U01 CA221046NIH HHS NIH U01CA221046Wellcome Trust WT088641/Z/09/Z
6 · The paper itself

Abstract

Pretargeting is widely explored in immunoPET as a strategy to reduce radiation exposure of non-target organs and allow the use of short-lived radionuclides that would not otherwise be compatible with the slow pharmacokinetic profiles of antibodies. Here we investigate a pretargeting strategy based on gallium-68 and the chelator THP

Indexed as

AnimalsAntibodiesCell Line, TumorChelating AgentsFemaleGallium RadioisotopesHeterograftsHumansImmunoconjugatesMetabolic Clearance RateMice, Inbred BALB CMice, NudeMolecular StructurePositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionAntibodiesChelating AgentsGallium-68Gallium RadioisotopesImmunoconjugatesRadiopharmaceuticalsbifunctional chelatorsgallium-68hydroxypyridinonesmetal chelationmonoclonal antibodiespretargetingradionuclide imaging

Identifiers

PMID32098299
PMCPMC7073083
OpenAlexW3008562659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.