Evidence map›Paper›PMID 32098215›Full record

ReviewJournal of clinical medicine2020

Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter.

Claudio Iovino, Marco Pellegrini, Federico Bernabei, Enrico Borrelli, Riccardo Sacconi, Andrea Govetto, Aldo Vagge, Antonio Di Zazzo, Matteo Forlini, Lucia Finocchio and 3 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Choroidal vascularity across aging and the spectrum of age-related macular degeneration: an AI-based OCT study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  4. Article
  5. Choriocapillaris flow deficits and choroidal vascular index in the fellow eye of patients with central serous chorioretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Three-dimensional choroidal vessels assessment in central serous chorioretinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  13. Article
  14. Article
  15. Volumetric choroidal biomarkers in central serous chorioretinopathy using swept-source optical coherence tomography: a deep learning approach.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Evaluation of retina and choroidInternational journal of ophthalmology · 2026
    Article
  20. Review

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claudio IovinoDepartment of Surgical Sciences, Eye Clinic, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0003-1984-0555
Marco PellegriniOphthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-6419-6941
Federico BernabeiOphthalmology Unit, S. Orsola-Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy.
Enrico BorrelliDepartment of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, 20132 Milan, Italy.
Riccardo SacconiDepartment of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, 20132 Milan, Italy.
Andrea GovettoOphthalmology Department, Fatebenefratelli and Ophthalmic Hospital, ASST-Fatebenefratelli-Sacco, 63631 Milan, Italy.
Aldo VaggeUniversity Eye Clinic, DINOGMI, Polyclinic Hospital San Martino IRCCS, 16132 Genoa, Italy.ORCID 0000-0002-9346-9267
Antonio Di ZazzoDepartment of Ophthalmology, University Campus Bio-Medico of Rome, 00128 Rome, Italy.
Matteo ForliniDomus Nova Hospital, 48121 Ravenna, Italy.
Lucia FinocchioDepartment of Translational Surgery and Medicine, Ophthalmology, University of Florence, 50134 Careggi Florence, Italy.ORCID 0000-0003-1986-045X
Adriano CarnevaliDepartment of Ophthalmology, University "Magna Graecia", 88100 Catanzaro, Italy.
Giacinto TrioloOphthalmology Department, Fatebenefratelli and Ophthalmic Hospital, ASST-Fatebenefratelli-Sacco, 63631 Milan, Italy.
Giuseppe GiannaccareDepartment of Ophthalmology, University "Magna Graecia", 88100 Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remarkable improvements in optical coherence tomography (OCT) technology have resulted in highly sophisticated, noninvasive machines allowing detailed and advanced morphological evaluation of all retinal and choroidal layers. Postproduction semiautomated imaging analysis with dedicated public-domain software allows precise quantitative analysis of binarized OCT images. In this regard, the choroidal vascularity index (CVI) is emerging as a new imaging tool for the measurement and analysis of the choroidal vascular system by quantifying both luminal and stromal choroidal components. Numerous reports have been published so far regarding CVI and its potential applications in healthy eyes as well as in the evaluation and management of several chorioretinal diseases. Current literature suggests that CVI has a lesser variability and is influenced by fewer physiologic factors as compared to choroidal thickness. It can be considered a relatively stable parameter for evaluating the changes in the choroidal vasculature. In this review, the principles and the applications of this advanced imaging modality for studying and understanding the contributing role of choroid in retinal and optic nerve diseases are discussed. Potential advances that may allow the widespread adoption of this tool in the routine clinical practice are also presented.

Indexed as

choroidal imaging biomarkerschoroidal vascularity indexoptical coherence tomographyretinal imaging

Identifiers

PMID32098215
PMCPMC7074450

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.