Evidence map›Paper›PMID 32098115›Full record

ArticleInternational journal of molecular sciences2020

Hypercapnia Impairs Na,K-ATPase Function by Inducing Endoplasmic Reticulum Retention of the β-Subunit of the Enzyme in Alveolar Epithelial Cells.

Vitalii Kryvenko, Miriam Wessendorf, Rory E Morty, Susanne Herold, Werner Seeger, Olga Vagin, Laura A Dada, Jacob I Sznajder, István Vadász

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. In Search of a Sensor: How Does COAmerican journal of respiratory cell and molecular biology · 2021
    Article
  8. Article
  9. Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  10. Review
  11. Elevated COInterface focus · 2021
    Review
  12. Article
  13. Review
  14. Hypercapnia: An Aggravating Factor in Asthma.Journal of clinical medicine · 2020
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Vitalii KryvenkoDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Miriam WessendorfDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Rory E MortyDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Susanne HeroldDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Werner SeegerDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Olga VaginDepartment of Physiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Laura A DadaDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
István VadászDepartment of Internal Medicine, Justus Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), 35392 Giessen, Germany.
Cardio-Pulmonary Institute · DEGerman Center for Lung Research · DENorthwestern University · USUniversities of Giessen and Marburg Lung Center · DEUniversity of California, Los Angeles · US

Funding

Role of hypercapnia on the lung airwaysR01HL147070 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2019 to 2022
$1.9M
Bundesministerium für Bildung und Forschung (German Center for Lung Research [DZL/ALI 3.1])Deutsche Forschungsgemeinschaft KFO309/ MD/PhD start-up grantDeutsche Forschungsgemeinschaft KFO309/P5Deutsche Forschungsgemeinschaft The Cardio-Pulmonary Institute (EXC 2026; Project ID: 390649896)Hessisches Ministerium für Wissenschaft und Kunst (Landes-Offensive zur Entwicklung Wissenschaftlichökonomischer Exzellenz [LOEWE])NHLBI NIH HHS R01 HL147070NIH HHS HL-147070Von-Behring-Röntgen-Stiftung Project 66-LV07
6 · The paper itself

Abstract

Alveolar edema, impaired alveolar fluid clearance, and elevated CO

Indexed as

Protein FoldingA549 CellsAlveolar Epithelial CellsAnimalsCarbon DioxideEndoplasmic ReticulumHumansHypercapniaRatsSodium-Potassium-Exchanging ATPaseCarbon DioxideSodium-Potassium-Exchanging ATPasealveolar epitheliumcarbon dioxideendoplasmic reticulumhypercapniaNa,K-ATPaseprotein oxidationsodium transport

Identifiers

PMID32098115
PMCPMC7073107
OpenAlexW3008824018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.