Evidence map›Paper›PMID 32098080›Full record

ArticleInternational journal of molecular sciences2020

Development of a Modified Three-Day T-maze Protocol for Evaluating Learning and Memory Capacity of Adult Zebrafish.

Bui Thi Ngoc Hieu, Nguyen Thi Ngoc Anh, Gilbert Audira, Stevhen Juniardi, Rhenz Alfred D Liman, Oliver B Villaflores, Yu-Heng Lai, Jung-Ren Chen, Sung-Tzu Liang, Jong-Chin Huang and 1 more

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
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  5. Knockout of theZoological research · 2025
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  6. Frontiers in cell and developmental biology · 2025
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  11. Life (Basel, Switzerland) · 2024
    Article
  12. Article
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  14. Article
  15. Article
  16. Review
  17. Article
  18. Review of Copper and Copper Nanoparticle Toxicity in Fish.Nanomaterials (Basel, Switzerland) · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Bui Thi Ngoc HieuDepartment of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Nguyen Thi Ngoc AnhDepartment of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Gilbert AudiraDepartment of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Stevhen JuniardiDepartment of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Rhenz Alfred D LimanThe Graduate School, University of Santo Tomas, Manila 1015, Philippines.
Oliver B VillafloresDepartment of Biochemistry, Faculty of Pharmacy and Research Center for Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines.
Yu-Heng LaiDepartment of Chemistry, Chinese Culture University, Taipei 11114, Taiwan.
Jung-Ren ChenDepartment of Biological Science & Technology College of Medicine, I-Shou University, Kaohsiung 82445, Taiwan.
Sung-Tzu LiangDepartment of Bioscience Technology, Chung Yuan Christian University, Chung-Li 32023, Taiwan.
Jong-Chin HuangDepartment of Applied Chemistry, National Pingtung University, Pingtung 90003, Taiwan.ORCID 0000-0003-3997-1683
Chung-Der HsiaoDepartment of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.ORCID 0000-0002-6398-8672
Chung Yuan Christian University · TWUniversity of Santo Tomas · PHChinese Culture University · TWI-Shou University · TWNational Pingtung University · TWTon Duc Thang University · VN

Funding

Ministry of Science Technology, Taiwan 107-2622-B-033-001-CC2; 108-2622-B-033-001-CC2
6 · The paper itself

Abstract

A T-maze test is an experimental approach that is used in congenital research. However, the food reward-based protocol for the T-maze test in fish has low efficiency and a long training period. The aim of this study is to facilitate the T-maze conditions by using a combination of the principles of passive avoidance and a spatial memory test. In our modified T-maze settings, electric shock punishment (1-2 V, 0.3-0.5 mA) is given at the left arm, with a green cue at the right arm. Also, the depth of both arms of the T-maze was increased. The parameters measured in our T-maze design were latency, freezing time, and time spent in different areas of the T-maze. We validated the utility of our modified T-maze protocol by showing the consistent finding of memory impairment in ZnCl

Indexed as

AnimalsMaze LearningMemoryZebrafishleptin apassive avoidancespatial memoryT-mazezebrafishZnCl2

Identifiers

PMID32098080
PMCPMC7073029
OpenAlexW3008025546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.